利用肌动蛋白动力学进行网格蛋白介导的内吞作用。

Harnessing actin dynamics for clathrin-mediated endocytosis.

作者信息

Kaksonen Marko, Toret Christopher P, Drubin David G

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202, USA.

出版信息

Nat Rev Mol Cell Biol. 2006 Jun;7(6):404-14. doi: 10.1038/nrm1940.

DOI:10.1038/nrm1940

PMID:16723976

Abstract

Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells. A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane--namely endocytosis--has recently been established. Live-cell imaging studies are shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.

摘要

肌动蛋白聚合作用通常发生在质膜处，以驱动迁移细胞前缘片状伪足和丝状伪足的突出。最近已确定肌动蛋白聚合作用在另一个涉及质膜重塑的细胞过程（即内吞作用）中发挥作用。活细胞成像研究正在揭示内吞作用过程中肌动蛋白功能的分子事件和机制的顺序及时间安排。