Department of Cell Biology, Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Curr Opin Cell Biol. 2024 Aug;89:102401. doi: 10.1016/j.ceb.2024.102401. Epub 2024 Jul 16.
Synthesizing the recent progresses, we present our perspectives on how local modulations of membrane curvature, tension, and bending energy define the feedback controls over membrane traffic processes. We speculate the potential mechanisms of, and the control logic behind, the different membrane mechanics-mediated feedback in endocytosis and exo-endocytosis coupling. We elaborate the path forward with the open questions for theoretical considerations and the grand challenges for experimental validations.
综合近期的进展，我们提出了自己的观点，即膜曲率、张力和弯曲能的局部调节如何定义对膜运输过程的反馈控制。我们推测了内吞作用和内吞外排偶联中不同的膜力学介导反馈背后的潜在机制和控制逻辑。我们详细阐述了理论考虑的前进道路和实验验证的重大挑战的开放性问题。
