Chaube Amita, Tewari Mallika, Singh Usha, Shukla H S
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
J Surg Oncol. 2006 Jun 15;93(8):665-9. doi: 10.1002/jso.20534.
CA 125 is a glycoprotein and a commonly used tumor marker in ovarian carcinoma. Its use in gallbladder carcinoma (GBC) has not yet been reported. We have henceforth examined for the first time the diagnostic utility of CA 125 in patients with gallbladder diseases.
Serum CA 125 was measured in 64 patients with GBC, 47 Gallstone disease (GSD) and 23 healthy volunteers by ELISA. CA 125 level was compared between different cohorts by non-parametric test (Kruskal Wallis and Mann-Whitney test). Receiver operating characteristic curve (ROC) was constructed to see the diagnostic utility of CA 125. Its level was also correlated with age, sex and clinico-pathological parameters of the patients included in the study.
Mean value of CA 125 in patients with GBC, GSD and healthy volunteers was 77.44 +/- 141.31 U/ml, 7.85 +/- 5.40 U/ml, and 8.08 +/- 3.26 U/ml respectively and showed a statistically significant difference (P < 0.001). CA 125 at cut off value of 11 U/ml yielded 64% sensitivity and 90% specificity in differentiating benign from malignant gallbladder disease. CA 125 level increased with stage and grade of the GBC though this was not statistically significant. A higher level of CA 125 was found in presence of gallbladder mass, weight loss, ascites and loss of appetite compared to patients with GSD. No association of CA 125 was apparent with either age or sex of the patients.
CA 125 has a diagnostic potential for GBC and can differentiate GBC from GSD in light of other clinical details.
CA 125是一种糖蛋白，是卵巢癌中常用的肿瘤标志物。其在胆囊癌（GBC）中的应用尚未见报道。因此，我们首次研究了CA 125在胆囊疾病患者中的诊断效用。
采用酶联免疫吸附测定法（ELISA）检测64例胆囊癌患者、47例胆结石疾病（GSD）患者和23名健康志愿者的血清CA 125。通过非参数检验（Kruskal Wallis和Mann-Whitney检验）比较不同队列之间的CA 125水平。构建受试者工作特征曲线（ROC）以观察CA 125的诊断效用。其水平还与研究中纳入患者的年龄、性别和临床病理参数相关。
胆囊癌患者、胆结石疾病患者和健康志愿者的CA 125平均值分别为77.44±141.31 U/ml、7.85±5.40 U/ml和8.08±3.26 U/ml，差异具有统计学意义（P<0.001）。CA 125临界值为11 U/ml时，在鉴别良性与恶性胆囊疾病方面的灵敏度为64%，特异度为90%。胆囊癌的CA 125水平随分期和分级增加，尽管无统计学意义。与胆结石疾病患者相比，胆囊肿块、体重减轻、腹水和食欲不振患者的CA 125水平更高。CA 125与患者的年龄或性别均无明显关联。
CA 125对胆囊癌具有诊断潜力，结合其他临床细节可将胆囊癌与胆结石疾病区分开来。
