Giulia Malaguarnera, Clorinda Mazzarino, Department of Biomedical Science, University of Catania, via Androne 83, 95124 Catania, Italy.
World J Gastrointest Oncol. 2011 Apr 15;3(4):49-59. doi: 10.4251/wjgo.v3.i4.49.
Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; therapeutic treatment options are often limited and of minimal utility. Recent studies have shown the importance of serum and molecular markers in the diagnosis and follow up of biliary tract tumors. This review aims to introduce the main features of the most important serum and molecular markers of biliary tree tumors. Some considerable tumor markers are cancer antigen 125, carbohydrate antigen 19-9, carcinoembryonic antigen, chromogranin A, mucin 1, mucin 5, alpha-fetoprotein, claudins and cytokeratins.
胆道癌相对少见，占癌症的比例不到 1%。然而，在日本和美国等工业化国家，其发病率有所增加。胆道肿瘤预后不良，死亡率高，因为它们通常在疾病过程的晚期才被发现；治疗选择往往有限，效果甚微。最近的研究表明，血清和分子标志物在胆道肿瘤的诊断和随访中具有重要意义。本综述旨在介绍胆道肿瘤最重要的血清和分子标志物的主要特征。一些重要的肿瘤标志物有癌抗原 125、糖类抗原 19-9、癌胚抗原、嗜铬粒蛋白 A、黏蛋白 1、黏蛋白 5、甲胎蛋白、claudins 和细胞角蛋白。
