Martin J C, Klug E, Merkt H, Himmler V, Jöchle W
Klinik fuer Andrologie und Besamung der Haustiere, Tieraerztliche Hochschule, Bischofsholer Damm 15, D-3000 Hannover 1, German FR.
Theriogenology. 1981 Oct;16(4):433-46. doi: 10.1016/0093-691x(81)90076-5.
Over a period of three years, 165 cyclic or anestrous Hanoverian mares received 177 treatments with 2, 3 or 4 mg of a novel luteolytic prostaglandin analog, K 11941. Heat and ovulations, indicating luteolysis, were observed after an average of 3.98 and 7.62 days, respectively, in 88.04% of 142 treated cyclic, postpartum and anestrous mares, and mares after an early loss of the conceptus. All doses tested were effective in inducing luteolysis as confirmed by determination of progesterone blood levels in samples collected daily, in 70 of 80 mares studied (87.5%). Attempts to achieve control of the cycle by various methods revealed that with K 11941 given once or twice, alone or in combination with hCG and/or an GnRH analog (Hoe 766), one can effectively concentrate estrus periods and follicular growth patterns, but can neither synchronize nor concentrate ovulations. Since most of the mares treated were confirmed problem mares, the pregnancy rate of 40.0% from first insemination at drug induced estrus, was regarded as satisfactory when compared to a pregnancy rate of 43.8% obtained with natural breeding in the same population. No drug related clinical signs of side-effects were observed.
在三年时间里，165匹处于发情周期或不发情的汉诺威母马接受了177次用2毫克、3毫克或4毫克新型溶黄体前列腺素类似物K 11941的治疗。在142匹接受治疗的处于发情周期、产后及不发情的母马以及早期胚胎丢失后的母马中，分别有88.04%的母马在平均3.98天和7.62天后出现了表明黄体溶解的发情和排卵现象。通过对每天采集的样本进行孕酮血水平测定证实，所测试的所有剂量在诱导黄体溶解方面均有效，在80匹研究母马中有70匹（87.5%）出现这种情况。通过各种方法尝试控制发情周期发现，单独或与hCG和/或促性腺激素释放激素类似物（Hoe 766）联合使用一次或两次K 11941，可以有效地集中发情期和卵泡生长模式，但既不能使排卵同步也不能使排卵集中。由于接受治疗的大多数母马被确认为有问题的母马，与同一群体自然配种获得的43.8%的妊娠率相比，药物诱导发情时首次输精的妊娠率为40.0%被认为是令人满意的。未观察到与药物相关的临床副作用迹象。
