Hamm D, Witherspoon D M, Buell J R, Chen C L, Jöchle W
Fayetteville, AK 72701 USA.
Theriogenology. 1981 Oct;16(4):447-57. doi: 10.1016/0093-691x(81)90077-7.
In trials covering two seasons, 124 thoroughbred and 40 quarterhorse mares with either normal cycles (55 diestrous mares, 33 postpartum mares after foal heat) or in anestrus during the breeding season (76) were treated with either a novel PGF analog K 11941 or with the PGF analog prostalene (Synchrocept(trade mark)). K 11941 was used over a range of doses from 0.5 to 4.5 mg, while prostalene was applied at the recommended dose level of 2 mg. Blood progesterone determinations, clinical observations and the results of breeding confirmed that K 11941, at doses of 2 mg or larger, and prostalene, were effective and safe luteolysins; heat and ovulations occurred within the expected time intervals and fertility was satisfactory. Clinical data were converted into a response score (CRS) and an added fertility score (CRSF) for statistical evaluation and the establishment of a dose response curve. In both scores, 0.5 to 1.5 mg were significantly less effective than the higher dose levels (p<.0001). No significant differences were found for the 2 and 3 mg dose of K 11941 in diestrous and anestrous mares. In both indications, prostalene scored less (p<.05). Data analysis and establishment of a dose response curve point to 3 mg of K 11941 as the optimal dose.
在涵盖两个季节的试验中，124匹纯种母马和40匹夸特马母马，其发情周期正常（55匹处于间情期的母马，33匹产后驹热后的母马）或在繁殖季节处于乏情期（76匹），分别用新型前列腺素F2α类似物K 11941或前列腺素F2α类似物前列烯醇（Synchrocept（商标））进行治疗。K 11941的使用剂量范围为0.5至4.5毫克，而前列烯醇则按推荐剂量2毫克使用。血液孕酮测定、临床观察和配种结果证实，2毫克及以上剂量的K 11941和前列烯醇是有效且安全的溶黄体素；发情和排卵在预期时间间隔内发生，繁殖力令人满意。临床数据被转换为反应评分（CRS）和附加繁殖力评分（CRSF），用于统计评估和建立剂量反应曲线。在这两个评分中，0.5至1.5毫克的效果明显低于较高剂量水平（p<0.0001）。在间情期和乏情期母马中，2毫克和3毫克剂量的K 11941未发现显著差异。在两种适应症中，前列烯醇的评分较低（p<0.05）。数据分析和剂量反应曲线的建立表明，3毫克的K 11941为最佳剂量。
