通过抑制前列腺素合成预防催产素对山羊的黄体溶解作用。
Prevention of the luteolytic action of oxytocin in the goat by inhibition of prostaglandin synthesis.
作者信息
Cooke R G, Homeida A M
机构信息
Department of Veterinary Physiology and Pharmacology, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX UK.
出版信息
Theriogenology. 1983 Sep;20(3):363-5. doi: 10.1016/0093-691x(83)90070-5.
Oxytocin-induced luteolysis in goats was associated with significant increases in peripheral plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F2alpha (PGFM). Oral administration of the prostaglandin (PG) synthetase inhibitor meclofenamic acid (l g/day) prevented both the luteolytic action of oxytocin and the increase in PGFM concentrations. These results confirm that the luteolytic effect of oxytocin is mediated via the production and release of PGF2alpha.
催产素诱导山羊黄体溶解与外周血浆中13,14-二氢-15-酮-前列腺素F2α（PGFM）浓度显著升高有关。口服前列腺素（PG）合成酶抑制剂甲氯芬那酸（1克/天）可防止催产素的黄体溶解作用以及PGFM浓度的升高。这些结果证实，催产素的黄体溶解作用是通过PGF2α的产生和释放介导的。
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