Hinrichs K, Sertich P L, Kenney R M
Section of Reproductive Studies, New Bolton Center School of Veterinary Medicine University of Pennsylvania Kennett Square, PA 19348 USA.
Theriogenology. 1986 Oct;26(4):455-60. doi: 10.1016/0093-691x(86)90037-3.
Altrenogest was administered to ovariectomized mares to determine if treatment would enable establishment and maintenance of pregnancy after transfer of a 7-d embryo. Three different treatment regimens were used: Group A received 22 mg altrenogest daily starting 5 d before transfer, Group B received 66 mg altrenogest daily starting 6 days before transfer, Group C received 300 mg progesterone in oil intramuscularly daily starting 5 d before transfer. Intact, ovulation-synchronized recipients were used as controls for transfer technique. Pregnancy rates were 1 6 , 2 6 , 2 5 , and 13 19 for Group A, Group B, Group C, and controls, respectively. The pregnancy rate in Group A was significantly different from controls and Group A mares had poor uterine and cervical tone. These results show that ovariectomized mares treated with altrenogest are capable of establishing pregnancy after embryo transfer. Treatment with 22 mg altrenogest appears to be insufficient for optimal pregnancy rates after transfer in ovariectomized recipients.
对去卵巢母马施用烯丙孕素，以确定该治疗是否能使7天胚胎移植后成功建立并维持妊娠。使用了三种不同的治疗方案：A组在移植前5天开始每天接受22毫克烯丙孕素；B组在移植前6天开始每天接受66毫克烯丙孕素；C组在移植前5天开始每天肌肉注射300毫克油剂孕酮。完整的、排卵同步的受体用作移植技术的对照。A组、B组、C组和对照组的妊娠率分别为1/6、2/6、2/5和13/19。A组的妊娠率与对照组有显著差异，且A组母马子宫和宫颈张力较差。这些结果表明，用烯丙孕素治疗的去卵巢母马在胚胎移植后能够成功妊娠。对于去卵巢受体，移植后使用22毫克烯丙孕素治疗似乎不足以获得最佳妊娠率。
