Leite de Moraes M C, Hontebeyrie-Joskowicz M, Leboulenger F, Savino W, Dardenne M, Lepault F
INSERM U 25, CNRS UA 122, Hôpital Necker, Paris, France.
Scand J Immunol. 1991 Mar;33(3):267-75. doi: 10.1111/j.1365-3083.1991.tb01772.x.
Changes in thymic T-cell subsets in mice acutely infected with Trypanosoma cruzi have been studied in both C3H/HeJ and C57BL/6 mice. The significant decrease in thymocyte number, observed in both mouse strains on day 14 post-infection correlated with a drastic decrease in CD4+CD8+ cell number, whereas the number of CD4-CD8-, CD4+CD8- and CD4-CD8+ cells remained essentially unchanged. The important increase in CD3hi cell frequency confirmed that resistant thymocytes during Chagas' disease development were mostly medullary thymocytes, whereas the thymic cortex was largely depleted, as previously observed on thymus sections. This involution of the thymus could have been due to the increase of circulating glucocorticoid levels observed after infection. However, similar cell modifications were found in infected adrenalectomized mice whose serum corticosterone levels were only slightly augmented. Thus, the thymic alterations appear not to be linked to stress responses, at least those dependent on high levels of circulating glucocorticoids.
在C3H/HeJ和C57BL/6小鼠中，研究了急性感染克氏锥虫的小鼠胸腺T细胞亚群的变化。在感染后第14天，两种小鼠品系中均观察到胸腺细胞数量显著减少，这与CD4⁺CD8⁺细胞数量的急剧减少相关，而CD4⁻CD8⁻、CD4⁺CD8⁻和CD4⁻CD8⁺细胞数量基本保持不变。CD3hi细胞频率的显著增加证实，恰加斯病发展过程中的抗性胸腺细胞大多是髓质胸腺细胞，而胸腺皮质大量耗竭，正如先前在胸腺切片上观察到的那样。胸腺的这种退化可能是由于感染后循环糖皮质激素水平升高所致。然而，在感染的肾上腺切除小鼠中也发现了类似的细胞变化，其血清皮质酮水平仅略有升高。因此，胸腺改变似乎与应激反应无关，至少与那些依赖高水平循环糖皮质激素的应激反应无关。
