Ornat S Ia
Vrach Delo. 1991 Jan(1):61-5.
The author studied the content of corticotropin, cortisol, aldosterone, insulin in the blood serum of 69 patients with rheumatoid arthritis depending on the grade of activity of the inflammatory process before treatment in the course of aurotherapy within 12 months. It was established that in patients with rheumatoid arthritis changes develop in the system of pituitary-peripheral endocrine glands, namely, an increase of the concentration of corticotropin, aldosterone and a reduction of the level of cortisol and insulin indicating the participation of hormones in the pathogenesis of rheumatoid arthritis. Non-steroid antiinflammatory preparations and quinolinic derivatives did not effect the hormonal spectrum of rheumatoid arthritis. Prolonged aurotherapy resulted in a positive dynamics in the contents of hormones.
作者研究了69例类风湿性关节炎患者血清中促肾上腺皮质激素、皮质醇、醛固酮、胰岛素的含量,这些患者在接受金疗法治疗的12个月期间,根据治疗前炎症过程的活动程度进行分组。结果发现,类风湿性关节炎患者垂体-外周内分泌腺系统会发生变化,即促肾上腺皮质激素、醛固酮浓度升高,皮质醇和胰岛素水平降低,这表明激素参与了类风湿性关节炎的发病机制。非甾体抗炎制剂和喹啉衍生物对类风湿性关节炎的激素谱没有影响。长期金疗法使激素含量出现了积极的变化。