Hulshof S C, Figueiredo J R, Beckers J F, Bevers M M, Vanderstichele H, van den Hurk R
Department of Functional Morphology/Herd Health and Reproduction Faculty of Veterinary Medicine, 3508 TD Utrecht, The Netherlands.
Theriogenology. 1997 Jul 1;48(1):133-42. doi: 10.1016/S0093-691X(97)00196-9.
Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantral follicles. In addition, activin immunoreactivity was observed in the theca of secondary follicles. During culture of isolated preantral follicles, activin increased follicular growth and granulosa cell proliferation in a dose-dependent manner. This increase was further stimulated by addition of FSH. In conclusion, activin and its receptor are present on bovine preantral follicles, and additional activin stimulates development of those follicles.
