药物释放与渗透的外部控制：超声辐照增强吲哚美辛的透皮吸收

External control of drug release and penetration: enhancement of the transdermal absorption of indomethacin by ultrasound irradiation.

作者信息

Miyazaki S, Mizuoka H, Oda M, Takada M

机构信息

Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.

出版信息

J Pharm Pharmacol. 1991 Feb;43(2):115-6. doi: 10.1111/j.2042-7158.1991.tb06643.x.

DOI:10.1111/j.2042-7158.1991.tb06643.x

PMID:1672894

Abstract

The effect of ultrasound (1 MHz) on transdermal absorption of indomethacin from an ointment has been studied in rats. Ultrasound energy was supplied for 10 min at a range of intensities (0.25, 0.5 and 0.75 W cm-2), energy levels commonly used for therapeutic purposes. The pronounced effect of ultrasound on transdermal absorption of indomethacin was observed for all three intensities studied. The mean AUC value (33.22 micrograms h mL-1) after irradiation at 0.75 W cm-2 was 3.4 times the control value (9.70 micrograms h mL-1).

摘要

在大鼠中研究了超声（1兆赫）对吲哚美辛软膏经皮吸收的影响。在一系列强度（0.25、0.5和0.75瓦/平方厘米）下提供超声能量10分钟，这些能量水平常用于治疗目的。在所研究的所有三种强度下均观察到超声对吲哚美辛经皮吸收有显著影响。在0.75瓦/平方厘米照射后的平均AUC值（33.22微克·小时/毫升）是对照值（9.70微克·小时/毫升）的3.4倍。