Thompson Katherine H, Barta Cheri A, Orvig Chris
Medicinal Inorganic Chemistry Group, Chemistry Department, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
Chem Soc Rev. 2006 Jun;35(6):545-56. doi: 10.1039/b416256k. Epub 2006 Apr 12.
The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly versatile class of ligands. The most widely investigated for medicinal applications are the 3-hydroxy-4-pyrones and the 1,2- 3,2- and 3,4-hydroxypyridinones. Key features of these ligands are: a six-membered ring, with a ring N or O atom either ortho or para to a ketone group, and two ortho exocyclic oxygen atoms. Readily functionalizable, the hydroxypyrones and hydroxypyridinones allow one to achieve a range of di- and trivalent metallocomplex stabilities and can include tissue or molecular targeting features by design. Research over the past several decades has greatly expanded the array of ligands that are the subject of this critical review. Ligand applications as diverse as iron removal or supplementation, contrast agents in imaging applications, and mobilization of undesirable excess metal ions will be surveyed herein.
羟基吡喃酮及其类似物羟基吡啶酮家族是一类特别通用的配体。在医学应用中研究最广泛的是3-羟基-4-吡喃酮以及1,2-、3,2-和3,4-羟基吡啶酮。这些配体的关键特征包括：一个六元环，环上的氮或氧原子与酮基处于邻位或对位，以及两个邻位的环外氧原子。羟基吡喃酮和羟基吡啶酮易于功能化，能够实现一系列二价和三价金属配合物的稳定性，并且可以通过设计包含组织或分子靶向特征。过去几十年的研究极大地扩展了作为本重要综述主题的配体种类。本文将概述配体在诸如铁去除或补充、成像应用中的造影剂以及去除不需要的过量金属离子等多种不同方面的应用。
