Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Dipartimento di Scienze della Vita e dell'Ambiente, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.
Biomolecules. 2024 Jan 11;14(1):92. doi: 10.3390/biom14010092.
Because of their capacity to bind metals, metal chelators are primarily employed for therapeutic purposes, but they can also find applications as colorimetric reagents and cleaning solutions as well as in soil remediation, electroplating, waste treatment, and so on. For instance, iron-chelation therapy, which is used to treat iron-overload disorders, involves removing excess iron from the blood through the use of particular molecules, like deferoxamine, that have the ability to chelate the metal. The creation of bioinspired and biodegradable chelating agents is a crucial objective that draws inspiration from natural products. In this context, starting from bioavailable molecules such as maltol and pyrogallol, new molecules have been synthetized and characterized by potentiometry, infrared spectroscopy and cyclic voltammetry. Finally, the ability of these to bind iron has been investigated, and the stability constants of ferric complexes are measured using spectrophotometry. These compounds offer intriguing scaffolds for an innovative class of versatile, multipurpose chelating agents.
由于金属螯合剂能够结合金属，因此主要用于治疗目的，但它们也可以用作比色试剂和清洁剂，以及用于土壤修复、电镀、废物处理等。例如，铁螯合疗法用于治疗铁过载疾病，通过使用特定的分子，如去铁胺，从血液中去除多余的铁，这些分子具有螯合金属的能力。受天然产物启发，开发生物启发和可生物降解的螯合剂是一个关键目标。在这种情况下，从生物可用的分子如麦芽酚和焦棓酚出发，通过电位法、红外光谱法和循环伏安法合成和表征了新的分子。最后，研究了这些分子与铁结合的能力，并通过分光光度法测量了三价铁配合物的稳定常数。这些化合物为一类创新的多功能螯合剂提供了有趣的支架。
