Clemens J D, van Loon F, Sack D A, Rao M R, Ahmed F, ChakrabortY J, Kay B A, Khan M R, Yunus M D, Harris J R
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
Lancet. 1991 Apr 13;337(8746):883-4. doi: 10.1016/0140-6736(91)90207-6.
To test the hypothesis that clinical Vibrio cholerae O1 infections protect against recurrent cholera, treated cholera episodes in a rural Bangladesh population of 188,153 people who were followed between 1985 and 1988 were analysed. Of the 2214 people with initial episodes of cholera, 7 had a second episode. The incidence of cholera was 61% lower in subjects who had had an earlier episode than in those without such an episode. Whereas initial episodes of classical cholera were associated with complete protection against subsequent cholera, initial episodes of El Tor cholera were associated with negligible protection.
为验证霍乱弧菌O1临床感染可预防霍乱复发这一假说，对1985年至1988年期间在孟加拉国农村地区随访的188153人所经历的霍乱治疗发作情况进行了分析。在2214例首次发作霍乱的患者中，7例出现了第二次发作。有过早期霍乱发作史的受试者霍乱发病率比无此发作史的受试者低61%。虽然典型霍乱的首次发作可提供完全的后续霍乱防护，但埃尔托霍乱的首次发作提供的防护可忽略不计。
