复发性流产与有机氯农药水平的关系。
Association between recurrent miscarriages and organochlorine pesticide levels.
机构信息
Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences & GTB Hospital, University of Delhi, Dilshad Garden, Delhi 110 095, India.
出版信息
Clin Biochem. 2010 Jan;43(1-2):131-5. doi: 10.1016/j.clinbiochem.2009.09.019. Epub 2009 Oct 3.
OBJECTIVES
Recurrent miscarriage (RM) is a challenging medical problem because of its unknown pathogenesis and etiology in most of the cases. Recent studies suggest the role of persistent environmental pollutants such as organochlorine pesticides (OCPs) in the etiology of RM. The present study was conducted to investigate possible associations of OCPs in the pathogenesis of RM.
DESIGN AND METHODS
Blood OCP levels were analyzed in women with RM (cases) and women with normal full term delivery with live birth (controls) by using a gas chromatograph equipped with an electron capture detector.
RESULTS
A statistically significant association (p=0.01) was observed between blood gamma-HCH levels and women with recurrent miscarriages.
CONCLUSIONS
This study suggests that high blood levels of gamma-HCH may be associated with risk of RM.
目的
复发性流产（RM）是一个具有挑战性的医学问题，因为在大多数情况下，其发病机制和病因尚不清楚。最近的研究表明，持久性环境污染物（如有机氯农药（OCPs））在 RM 的病因学中起作用。本研究旨在探讨 OCP 在 RM 发病机制中的可能作用。
设计和方法
采用配备电子捕获检测器的气相色谱仪检测 RM 患者（病例）和足月分娩活产妇女（对照）的血液 OCP 水平。
结果
观察到血液γ-HCH 水平与复发性流产患者之间存在统计学显著关联（p=0.01）。
结论
本研究表明，血液中高水平的γ-HCH 可能与 RM 的风险相关。
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