Swann K, Saunders C M, Rogers N T, Lai F A
Department of Obstetrics and Gynaecology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Semin Cell Dev Biol. 2006 Apr;17(2):264-73. doi: 10.1016/j.semcdb.2006.03.009. Epub 2006 Apr 3.
At fertilization in mammals, the sperm activates development by causing a prolonged series of intracellular Ca(2+) oscillations that are generated by increased production of inositol trisphosphate (InsP(3)). It appears that the sperm initiates InsP(3) generation via the introduction of a sperm factor into the egg after gamete membrane fusion. We recently identified a sperm-specific form of phospholipase C (PLC), referred to as PLCzeta(zeta). We review the evidence that PLCzeta represents the sperm factor that activates development of the egg and discuss the characteristics of PLCzeta that distinguish it from the somatic forms of PLC.
在哺乳动物受精过程中，精子通过引发一系列由三磷酸肌醇（InsP(3)）生成增加所产生的长时间细胞内钙离子振荡来激活发育。精子似乎是在配子膜融合后通过向卵子中引入一种精子因子来启动InsP(3)的生成。我们最近鉴定出一种精子特异性的磷脂酶C（PLC）形式，称为PLCζ（ζ）。我们综述了支持PLCζ代表激活卵子发育的精子因子的证据，并讨论了PLCζ与体细胞形式的PLC相区别的特征。
