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精子特异性蛋白 ACTL7A 作为辅助生殖技术受精结局的生物标志物。

Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology.

机构信息

Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.

NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Pharmacy, Fudan University, Shanghai 200032, China.

出版信息

Asian J Androl. 2022 May-Jun;24(3):260-265. doi: 10.4103/aja2021111.

DOI:10.4103/aja2021111
PMID:35532568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9226699/
Abstract

Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies (ART). So far, the clinical evaluation of embryo quality depends on embryo morphology. However, the clinical pregnancy rate is still low. Therefore, new indicators are needed to further improve the evaluation of embryo quality. Several studies have shown that the decrease of sperm-specific protein actin-like 7A (ACTL7A) leaded to low fertilization rate, poor embryo development, and even infertility. The aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo quality. In this study, excluding the factors of severe female infertility, a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization (IVF) laboratory outcomes. Our results indicated that the ACTL7A levels were significantly reduced in sperm samples presenting poor embryo quality. Furthermore, the protein levels showed a significant correlation with fertilization outcomes of ART. ACTL7A has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo arrest. In conclusion, sperm-specific protein ACTL7A has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.

摘要

获得高质量的胚胎是提高辅助生殖技术（ART）临床妊娠率的关键因素之一。到目前为止，胚胎质量的临床评估依赖于胚胎形态。然而，临床妊娠率仍然很低。因此，需要新的指标来进一步提高胚胎质量的评估。几项研究表明，精子特异性蛋白肌动蛋白样 7A（ACTL7A）的减少导致受精率低、胚胎发育不良，甚至不孕。本研究旨在研究精子中不同表达水平的 ACTL7A 是否可以作为预测胚胎质量的生物标志物。在这项研究中，排除严重女性不孕的因素，共收集了 281 个精子样本，比较了高和低有效胚胎率的精子中 ACTL7A 的表达水平，并分析了蛋白水平与体外受精（IVF）实验室结果之间的相关性。我们的结果表明，在胚胎质量较差的精子样本中，ACTL7A 水平明显降低。此外，蛋白水平与 ART 的受精结果显著相关。ACTL7A 有可能成为预测受精成功率和有效胚胎及胚胎阻滞可能性的生物标志物。总之，精子特异性蛋白 ACTL7A 与 IVF 实验室结果具有很强的相关性，在受精和胚胎发育中起着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/c7670b851f9b/AJA-24-260-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/01245c5ea451/AJA-24-260-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/01742a1d2280/AJA-24-260-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/673860494940/AJA-24-260-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/2685e30df700/AJA-24-260-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/c7670b851f9b/AJA-24-260-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/01245c5ea451/AJA-24-260-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/01742a1d2280/AJA-24-260-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/673860494940/AJA-24-260-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/2685e30df700/AJA-24-260-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1822/9226699/c7670b851f9b/AJA-24-260-g005.jpg

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