Moss S F, Ind P W
Royal Postgraduate Medical School, Hammersmith Hospital, London.
Respir Med. 1991 Jan;85(1):73-5. doi: 10.1016/s0954-6111(06)80215-5.
Interstitial lung disease has long been recognized as one of the side effects of sulphonamide drugs (1) but we have found only 13 case reports of alveolitis in association with sulphasalazine (2-8). Although the clinical picture and radiological changes are known to be reversible, there is little information regarding the lung function abnormalities and no description of the time course of its recovery. We describe a patient with very severe impairment of gas exchange secondary to sulphasalazine which completely recovered after the drug was stopped.
间质性肺病长期以来一直被认为是磺胺类药物的副作用之一(1)，但我们仅发现13例与柳氮磺胺吡啶相关的肺泡炎病例报告(2 - 8)。虽然已知临床表现和影像学改变是可逆的，但关于肺功能异常的信息很少，也没有关于其恢复时间进程的描述。我们描述了一名因柳氮磺胺吡啶导致气体交换严重受损的患者，在停药后完全康复。
