Dickson Robert C, Sumanasekera Chiranthani, Lester Robert L
Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536-0509, USA.
Prog Lipid Res. 2006 Nov;45(6):447-65. doi: 10.1016/j.plipres.2006.03.004. Epub 2006 Apr 21.
We describe recent advances in understanding sphingolipid functions and metabolism in the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast sphingolipid research with the complete or nearly complete identification of genes involved in sphingolipid synthesis and breakdown. Other advances include roles for sphingolipid long-chain bases as signaling molecules that regulate growth, responses to heat stress, cell wall synthesis and repair, endocytosis and dynamics of the actin cytoskeleton. We touch briefly on other sphingolipid functions so that readers unfamiliar with the field will gain a broader view of sphingolipid research. These functions include roles in protein trafficking/exocytosis, lipid rafts or microdomains, calcium homeostasis, longevity and cellular aging, nutrient uptake, cross-talk with other lipids and the interaction of sphingolipids and antifungal drugs.
我们描述了在理解面包酵母酿酒酵母中鞘脂功能和代谢方面的最新进展。酵母鞘脂研究已取得一个里程碑式的成果，即已完全或几乎完全鉴定出参与鞘脂合成和分解的基因。其他进展包括鞘脂长链碱作为信号分子的作用，这些信号分子可调节生长、对热应激的反应、细胞壁的合成与修复、内吞作用以及肌动蛋白细胞骨架的动态变化。我们简要提及了鞘脂的其他功能，以便不熟悉该领域的读者对鞘脂研究有更广泛的了解。这些功能包括在蛋白质运输/胞吐作用、脂筏或微结构域、钙稳态、寿命和细胞衰老、营养物质摄取、与其他脂质的相互作用以及鞘脂与抗真菌药物的相互作用中所起的作用。
