Dosenbach Nico U F, Visscher Kristina M, Palmer Erica D, Miezin Francis M, Wenger Kristin K, Kang Hyunseon C, Burgund E Darcy, Grimes Ansley L, Schlaggar Bradley L, Petersen Steven E
Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Neuron. 2006 Jun 1;50(5):799-812. doi: 10.1016/j.neuron.2006.04.031.
When performing tasks, humans are thought to adopt task sets that configure moment-to-moment data processing. Recently developed mixed blocked/event-related designs allow task set-related signals to be extracted in fMRI experiments, including activity related to cues that signal the beginning of a task block, "set-maintenance" activity sustained for the duration of a task block, and event-related signals for different trial types. Data were conjointly analyzed from mixed design experiments using ten different tasks and 183 subjects. Dorsal anterior cingulate cortex/medial superior frontal cortex (dACC/msFC) and bilateral anterior insula/frontal operculum (aI/fO) showed reliable start-cue and sustained activations across all or nearly all tasks. These regions also carried the most reliable error-related signals in a subset of tasks, suggesting that the regions form a "core" task-set system. Prefrontal regions commonly related to task control carried task-set signals in a smaller subset of tasks and lacked convergence across signal types.
在执行任务时,人们被认为会采用配置即时数据处理的任务集。最近开发的混合组块/事件相关设计允许在功能磁共振成像(fMRI)实验中提取与任务集相关的信号,包括与标志任务组块开始的线索相关的活动、在任务组块持续时间内持续的“集维持”活动,以及针对不同试验类型的事件相关信号。使用十个不同任务和183名受试者,对混合设计实验的数据进行了联合分析。背侧前扣带回皮质/内侧额上回(dACC/msFC)和双侧前岛叶/额盖(aI/fO)在所有或几乎所有任务中均显示出可靠的起始线索和持续激活。在一部分任务中,这些区域还携带了最可靠的错误相关信号,这表明这些区域形成了一个“核心”任务集系统。通常与任务控制相关的前额叶区域在较少的一部分任务中携带任务集信号,并且在信号类型之间缺乏聚合。