Tonnaer Edith L G M, Graamans Kees, Sanders Elisabeth A M, Curfs Jo H A J
Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, The Netherlands.
Pediatr Infect Dis J. 2006 Jun;25(6):546-52. doi: 10.1097/01.inf.0000222402.47887.09.
In this review, a state of the art on otitis media research is provided with emphasis on the role of Streptococcus pneumoniae in the pathogenesis of this disease. Articles have been selected by MEDLINE search supplemented with a manual crosscheck of bibliographies. Pathogenic mechanisms in middle ear and eustachian tube are described. Furthermore, pneumococcal characteristics and pneumococcus-host interactions are highlighted as well as the possible role of biofilms in persistence or recurrence of otitis media. Because of the availability of new techniques, an increasing number of pneumococcal features contributing in the pathogenesis of otitis media are identified and in-depth knowledge of pneumococcus-host interactions has been gained. The present advances in research on otitis media open up new perspectives for therapeutic or preventive strategies.
在本综述中，我们介绍了中耳炎研究的最新进展，重点阐述了肺炎链球菌在该疾病发病机制中的作用。通过医学文献数据库（MEDLINE）检索并辅以手动核对参考文献的方式筛选了相关文章。文中描述了中耳和咽鼓管的致病机制。此外，还强调了肺炎球菌的特性、肺炎球菌与宿主的相互作用，以及生物膜在中耳炎持续存在或复发中可能发挥的作用。由于新技术的出现，越来越多在中耳炎发病机制中起作用的肺炎球菌特征被识别出来，并且对肺炎球菌与宿主相互作用有了更深入的了解。目前中耳炎研究的进展为治疗或预防策略开辟了新的前景。
