Mizuno Yasutaka, Furusho Tadasu, Yoshida Ai, Nakamura Hironori, Matsuura Tomokazu, Eto Yoshikatsu
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
Pediatr Int. 2006 Jun;48(3):261-4. doi: 10.1111/j.1442-200X.2006.02200.x.
Vitamin A is an essential micronutrient with important roles in immunity and maintenance of normal epithelial cell differentiation. Little information is available regarding the relationship between vitamin A concentrations and asthma despite the repair of epithelial and other structural changes being of utmost importance for the relief of symptoms and control of the disease. The authors evaluated vitamin A and vitamin E concentrations in well-nourished children with asthma.
The serum vitamin A and vitamin E concentrations were measured by high performance liquid chromatography methods. Statistical analysis was performed using the Mann-Whitney U-test and Peason's correlation coefficient test.
According to these methods, the mean serum vitamin A concentrations were significantly lower (19.41+/-7.45 microg/dL, mean+/-SD) in asthmatic children than controls (29.52+/-11.34 microg/dL, P=0.0001). To compare the correlation of C-reactive protein and serum vitamin A concentrations, there was also significant difference between the two groups.
The data suggest that there is a correlation between vitamin A deficiency and the mechanism of asthmatic response. These data support that the mechanism of hypovitaminosis A in asthmatic children may involve not only the acute phase response but also the various degrees of chronic epitherial damage of airways.
维生素A是一种必需的微量营养素，在免疫及维持正常上皮细胞分化方面发挥着重要作用。尽管上皮修复及其他结构改变对于缓解症状和控制疾病至关重要，但关于维生素A浓度与哮喘之间的关系，目前所知甚少。作者对营养良好的哮喘儿童的维生素A和维生素E浓度进行了评估。
采用高效液相色谱法测定血清维生素A和维生素E浓度。使用曼-惠特尼U检验和皮尔逊相关系数检验进行统计分析。
根据这些方法，哮喘儿童的血清维生素A平均浓度（19.41±7.45微克/分升，均值±标准差）显著低于对照组（29.52±11.34微克/分升，P = 0.0001）。为比较C反应蛋白与血清维生素A浓度的相关性，两组之间也存在显著差异。
数据表明维生素A缺乏与哮喘反应机制之间存在相关性。这些数据支持哮喘儿童维生素A缺乏症的机制可能不仅涉及急性期反应，还涉及气道不同程度的慢性上皮损伤。
