Nakagawa M, Takeda K, Kakimoto Y
Department of Neuropsychiatry, School of Medicine, Ehime University, Japan.
Acta Psychiatr Scand. 1991 Feb;83(2):105-14. doi: 10.1111/j.1600-0447.1991.tb07374.x.
In a preliminary study, we noticed that alpha 2 activity in the frontal regions was suppressed less in schizophrenic patients than in other patients during the discriminative tasks. This was confirmed with 37 schizophrenic and 16 nonschizophrenic patients under the treatment of neuroleptics, 15 nonmedicated schizophrenic patients and 32 normal controls. The EEGs in eye-closed resting and during the auditory and visual discriminative tasks were recorded. Alpha 2 power values of the frontal, central, parietal, occipital and temporal regions in every subject group were processed by cluster analysis. During the discriminative tasks, the frontal regions were the most isolated cluster in schizophrenic patients and, in the normal and medicated nonschizophrenic groups, the frontal regions were incorporated in a different cluster. The same result was obtained by different statistical analyses of F-alpha 2 power ratio. The relative abundance of alpha 2 power value shifts from the occipital to the frontal regions during the discriminative tasks in schizophrenic patients. The weakened suppression of alpha 2 waves in the frontal regions by the discriminative tasks in schizophrenic patients supports the hypofrontal hypothesis of schizophrenia.
在一项初步研究中，我们注意到，在辨别任务期间，精神分裂症患者额叶区域的α2活动受抑制程度低于其他患者。这一发现已在37例接受抗精神病药物治疗的精神分裂症患者、16例非精神分裂症患者、15例未服药的精神分裂症患者以及32例正常对照者中得到证实。记录了闭眼静息状态以及听觉和视觉辨别任务期间的脑电图。对每个受试者组额叶、中央、顶叶、枕叶和颞叶区域的α2功率值进行聚类分析。在辨别任务期间，额叶区域在精神分裂症患者中是最孤立的聚类，而在正常组和服用药物的非精神分裂症组中，额叶区域则归为不同的聚类。通过对F-α2功率比进行不同的统计分析也得到了相同结果。在辨别任务期间，精神分裂症患者α2功率值的相对丰度从枕叶向额叶区域转移。精神分裂症患者辨别任务对额叶区域α2波抑制作用减弱，支持了精神分裂症的额叶功能低下假说。
