Grillon C, Ameli R, Courchesne E, Braff D L
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510-3223.
Schizophr Res. 1991 Jan-Feb;4(1):11-21. doi: 10.1016/0920-9964(91)90005-c.
The P3 component of the event-related potentials (ERPs) to auditory task-relevant and task-irrelevant stimuli in 'Attend Auditory' (i.e., reaction time task) and 'Attend Visual' (i.e., when the auditory stimuli were being ignored) conditions was investigated in 13 RDC/DSM-III diagnosed schizophrenic patients. ERPs were recorded from Fz, Cz, and Pz. Compared to controls, schizophrenics had a significantly smaller P3 in the Attend Auditory than in the Attend Visual condition and to the task-relevant than to the task-irrelevant stimuli. Furthermore, the patients' P3 response to the most salient task-irrelevant stimuli in the Attend visual condition was normal. The results are discussed as suggesting that schizophrenics either allocate relatively more resources to task-irrelevant than task-relevant stimuli or that they fail to habituate to task-irrelevant stimuli.
对13名经RDC/DSM-III诊断的精神分裂症患者，研究了在“专注听觉”（即反应时间任务）和“专注视觉”（即忽略听觉刺激时）条件下，与听觉任务相关和任务无关刺激的事件相关电位（ERP）的P3成分。ERP记录于Fz、Cz和Pz。与对照组相比，精神分裂症患者在专注听觉条件下的P3比在专注视觉条件下显著更小，对任务相关刺激的P3比对任务无关刺激的P3更小。此外，患者在专注视觉条件下对最突出的任务无关刺激的P3反应是正常的。讨论结果表明，精神分裂症患者要么将相对更多资源分配给任务无关刺激而非任务相关刺激，要么未能对任务无关刺激产生习惯化。
