Zarzycki Paweł K, Włodarczyk Elzbieta, Lou Da-Wei, Jinno Kiyokatsu
Laboratory of Toxicology, Department of Environmental Biology, Technical University of Koszalin, Poland.
Anal Sci. 2006 Mar;22(3):453-6. doi: 10.2116/analsci.22.453.
In the present study the solubility of beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin at sub-zero and elevated temperatures (-10 and +30 degrees C) for a given composition of methanol/water and acetonitrile/water binary mixtures (Xs = 0.16) was studied. Moreover, the freezing temperature profiles of acetonitrile-based chromatographic mobile phases were measured, and the obtained results were compared with data available in the literature. Furthermore, the effect of the macrocycles concentration on the liquid-phase freezing points was determined. The low solubility of native beta-cyclodextrin in a methanol/water mixture at sub-zero temperature as well as the non-linear behavior of acetonitrile/water mixtures that were observed concerning the freezing point profile are discussed from a practical point of view.
在本研究中，研究了在给定组成的甲醇/水和乙腈/水二元混合物（Xs = 0.16）中，β-环糊精和2-羟丙基-β-环糊精在零下和高温（-10和+30摄氏度）下的溶解度。此外，测量了基于乙腈的色谱流动相的冷冻温度曲线，并将所得结果与文献中的数据进行了比较。此外，还确定了大环化合物浓度对液相冰点的影响。从实际角度讨论了天然β-环糊精在零下温度下在甲醇/水混合物中的低溶解度以及观察到的乙腈/水混合物在冰点曲线上的非线性行为。
