Chiodera P, Coiro V
University Clinics of Endocrinology, School of Medicine, University of Parma.
J Neural Transm Gen Sect. 1991;83(1-2):121-6. doi: 10.1007/BF01244458.
In order to establish whether endogenous opioids play a role in the control of arginine vasopressin (AVP) response to insulin-induced hypoglycemia by interacting with somatostatin (SRIH), seven normal men were submitted to an insulin (0.15 U/kg) tolerance test (ITT) in the presence or absence of naloxone (10 mg in an i.v. bolus), SRIH (4.1 micrograms/min x 90 min) or the combination of the two substances. Plasma AVP concentrations rose significantly during ITT. The AVP response remained unchanged in the presence of naloxone, whereas it was significantly reduced by the treatment with SRIH. When both SRIH and naloxone were given, the hypoglycemia induced AVP rise was similar to that observed in the control test. These results indicate the involvement of naloxone sensitive endogenous opioids in the mechanism underlying SRIH inhibitory action, but not in the mediation of the AVP response to hypoglycemia.
为了确定内源性阿片类物质是否通过与生长抑素（SRIH）相互作用，在精氨酸加压素（AVP）对胰岛素诱导的低血糖反应的控制中发挥作用，七名正常男性在有或没有纳洛酮（静脉推注10毫克）、SRIH（4.1微克/分钟×90分钟）或两种物质联合使用的情况下，接受了胰岛素（0.15 U/kg）耐量试验（ITT）。在ITT期间，血浆AVP浓度显著升高。在纳洛酮存在的情况下，AVP反应保持不变，而用SRIH治疗则使其显著降低。当同时给予SRIH和纳洛酮时，低血糖诱导的AVP升高与对照试验中观察到的相似。这些结果表明，纳洛酮敏感的内源性阿片类物质参与了SRIH抑制作用的机制，但不参与AVP对低血糖反应的介导。
