短期和长期糖尿病对大鼠肉碱和肌醇的影响。

Effect of short- and long-term diabetes on carnitine and myo-inositol in rats.

Reddi A S, Jyothirmayi G N, DeAngelis B, Frank O, Baker H

Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103.

Comp Biochem Physiol A Comp Physiol. 1991;98(1):39-42. doi: 10.1016/0300-9629(91)90574-v.

Abstract

The effect of short- (2 wk) and long-term (20 wk) streptozotocin diabetes was studied on urine, blood, liver, heart, brain, skeletal muscle, pancreas and kidney concentrations of acid-soluble carnitine and free myo-inositol. 2. Short-term diabetic rats excreted significantly higher concentrations of carnitine as well as myoinositol than normal rats. Blood carnitine and myo-inositol were not different between normal and diabetic rats. Diabetes caused a decrease in liver, brain and pancreatic carnitine, but not in heart, skeletal muscle and kidney. Myo-inositol concentration was decreased in liver, heart and kidney but not in brain, pancreas and skeletal muscle. 3. Long-term diabetic rats had higher urinary excretions of both carnitine and myo-inositol. Blood carnitine did not change; however, myo-inositol was higher in diabetic than in normal rats. Diabetes caused a significant increase in liver and a decrease in heart, brain, skeletal muscle and pancreatic content of carnitine; no difference in kidney carnitine was noted. Myo-inositol content was elevated only in liver of diabetic rats. 4. We suggest that carnitine and myo-inositol concentrations are influenced both by short- and long-term diabetes through changes in tissue metabolism.

摘要

研究了短期（2周）和长期（20周）链脲佐菌素诱导的糖尿病对尿液、血液、肝脏、心脏、大脑、骨骼肌、胰腺和肾脏中酸溶性肉碱和游离肌醇浓度的影响。2. 短期糖尿病大鼠排出的肉碱和肌醇浓度显著高于正常大鼠。正常大鼠和糖尿病大鼠的血液肉碱和肌醇没有差异。糖尿病导致肝脏、大脑和胰腺中的肉碱减少，但心脏、骨骼肌和肾脏中的肉碱没有减少。肝脏、心脏和肾脏中的肌醇浓度降低，但大脑、胰腺和骨骼肌中的肌醇浓度没有降低。3. 长期糖尿病大鼠的尿液中肉碱和肌醇的排泄量都更高。血液肉碱没有变化；然而，糖尿病大鼠的血液肌醇高于正常大鼠。糖尿病导致肝脏中肉碱显著增加，心脏、大脑、骨骼肌和胰腺中的肉碱减少；肾脏肉碱没有差异。肌醇含量仅在糖尿病大鼠的肝脏中升高。4. 我们认为，短期和长期糖尿病通过组织代谢的变化影响肉碱和肌醇浓度。