急性和轻度链脲佐菌素诱导糖尿病大鼠组织中的游离和脂质肌醇
Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes.
作者信息
Palmano K P, Whiting P H, Hawthorne J N
出版信息
Biochem J. 1977 Oct 1;167(1):229-35. doi: 10.1042/bj1670229.
Abstract
Acute diabetes with ketosis was induced in rats by intraperitoneal streptozotocin and also a milder form of diabetes without ketosis by injecting less of the drug. The acutely diabetic rats were killed 72h after injection and the others after either 2 or 13 weeks. Free and lipid myo-inositol was then measured in various tissues and body fluids by g.l.c. of the trimethylsilyl ether. Serum inositol was increased in the acutely diabetic group, whereas liver inositol was decreased. Brain and kidney inositol concentrations were increased in the mildly diabetic animals at 13 weeks and there was a progressive decrease in sciatic-nerve inositol. Lipid inositol of sciatic nerve was decreased in the acutely diabetic group only. Brain lipid inositol concentration was decreased in mild diabetes at 13 weeks. Possible implications of these findings in relation to diabetic neuropathy was discussed.
摘要
通过腹腔注射链脲佐菌素在大鼠中诱导出伴有酮症的急性糖尿病，通过注射较少剂量的该药物诱导出较轻的无酮症糖尿病形式。急性糖尿病大鼠在注射后72小时处死，其他大鼠在2周或13周后处死。然后通过三甲基硅醚的气相色谱法测量各种组织和体液中的游离和脂质肌醇。急性糖尿病组血清肌醇增加，而肝脏肌醇减少。轻度糖尿病动物在13周时脑和肾肌醇浓度增加，坐骨神经肌醇逐渐减少。仅急性糖尿病组坐骨神经的脂质肌醇减少。轻度糖尿病在13周时脑脂质肌醇浓度降低。讨论了这些发现与糖尿病神经病变相关的可能意义。
相似文献
1
Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes.急性和轻度链脲佐菌素诱导糖尿病大鼠组织中的游离和脂质肌醇
Biochem J. 1977 Oct 1;167(1):229-35. doi: 10.1042/bj1670229.
2
Enzymes of myo-inositol and inositol lipid metabolism in rats with streptozotocin-induced diabetes.链脲佐菌素诱导糖尿病大鼠中肌醇和肌醇脂质代谢的酶
Biochem J. 1979 Jun 1;179(3):549-53. doi: 10.1042/bj1790549.
3
Changes in sorbitol, myo-inositol and lipid inositol in dorsal root and sympathetic ganglia from streptozotocin-diabetic rats.链脲佐菌素诱导的糖尿病大鼠背根神经节和交感神经节中山梨醇、肌醇和脂质肌醇的变化。
Diabetologia. 1986 Dec;29(12):876-81. doi: 10.1007/BF00870143.
4
Effect of short- and long-term diabetes on carnitine and myo-inositol in rats.短期和长期糖尿病对大鼠肉碱和肌醇的影响。
Comp Biochem Physiol A Comp Physiol. 1991;98(1):39-42. doi: 10.1016/0300-9629(91)90574-v.
5
Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil.实验性糖尿病中神经多元醇水平升高及索比尼尔对其的逆转作用。
Br J Exp Pathol. 1988 Oct;69(5):697-702.
6
Transport of myo-inositol into endoneurial preparations of sciatic nerve from normal and streptozotocin-diabetic rats.肌醇向正常大鼠和链脲佐菌素诱导的糖尿病大鼠坐骨神经神经内膜制剂中的转运。
Biochem J. 1983 Mar 15;210(3):775-81. doi: 10.1042/bj2100775.
7
Decreased incorporation of [3H]inositol and [3H]glycerol into glycerolipids of sciatic nerve from the streptozotocin diabetic rat.链脲佐菌素诱导的糖尿病大鼠坐骨神经甘油脂质中[3H]肌醇和[3H]甘油掺入减少。
J Neurochem. 1985 Aug;45(2):465-9. doi: 10.1111/j.1471-4159.1985.tb04011.x.
8
Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation.急性链脲佐菌素诱导糖尿病大鼠坐骨神经钠钾腺苷三磷酸酶受损及其通过膳食补充肌醇的纠正作用。
J Clin Invest. 1983 Sep;72(3):1058-63. doi: 10.1172/JCI111030.
9
Effect of cyclosporine treatment on carnitine and myo-inositol in diabetic rats.环孢素治疗对糖尿病大鼠肉碱和肌醇的影响。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992;101(1):151-3. doi: 10.1016/0742-8413(92)90213-q.
10
Nerve glucose, sorbitol, fructose, and myo-inositol at various time after feeding in streptozotocin-induced diabetes in rats.链脲佐菌素诱导的糖尿病大鼠进食后不同时间的神经葡萄糖、山梨醇、果糖和肌醇。
Mayo Clin Proc. 1989 Aug;64(8):905-10. doi: 10.1016/s0025-6196(12)61217-8.
引用本文的文献
1
Analysis of Scyllo-Inositol in a Wistar Rat Animal Model-A Preliminary Study.在Wistar大鼠动物模型中对异肌醇的分析——一项初步研究。
Pharmaceuticals (Basel). 2025 Jun 25;18(7):954. doi: 10.3390/ph18070954.
2
Lipidomic signatures in Colombian adults with metabolic syndrome.哥伦比亚患有代谢综合征的成年人的脂质组学特征。
J Diabetes Metab Disord. 2024 May 4;23(1):1279-1292. doi: 10.1007/s40200-024-01423-5. eCollection 2024 Jun.
3
Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach.基于代谢组学方法的枸杞皮层中分离出的降血糖成分9-(R)-羟基十八碳二烯酸的作用机制
Front Pharmacol. 2022 Oct 21;13:1011608. doi: 10.3389/fphar.2022.1011608. eCollection 2022.
4
-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases.肌醇及其衍生物：它们在人类疾病治疗中的新作用。
Front Pharmacol. 2019 Oct 11;10:1172. doi: 10.3389/fphar.2019.01172. eCollection 2019.
5
The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).“其他”肌醇及其磷酸盐：合成、生物学与医学（含肌醇化学的最新进展）
Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1614-50. doi: 10.1002/anie.201502227. Epub 2015 Dec 22.
6
Inositol synthesis regulates the activation of GSK-3α in neuronal cells.肌醇合成调节神经元细胞中GSK-3α的激活。
J Neurochem. 2015 Apr;133(2):273-83. doi: 10.1111/jnc.12978. Epub 2014 Nov 17.
7
Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier.血脑屏障处溶质载体基因家族的表达谱分析。
Front Pharmacol. 2012 Aug 24;3:154. doi: 10.3389/fphar.2012.00154. eCollection 2012.
8
Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.钠/肌醇转运蛋白：淀粉样蛋白病理 TgCRND8 小鼠模型中的底物转运要求和区域性脑表达。
PLoS One. 2011;6(8):e24032. doi: 10.1371/journal.pone.0024032. Epub 2011 Aug 26.
9
Transcriptional and post-translational modulation of myo-inositol oxygenase by high glucose and related pathobiological stresses.高血糖及相关病理生物应激对肌醇加氧酶的转录后和翻译后调节。
J Biol Chem. 2011 Aug 5;286(31):27594-611. doi: 10.1074/jbc.M110.217141. Epub 2011 Jun 7.
10
Metabolomics reveals relationship between plasma inositols and birth weight: possible markers for fetal programming of type 2 diabetes.代谢组学揭示血浆肌醇与出生体重之间的关系：2型糖尿病胎儿编程的潜在标志物。
J Biomed Biotechnol. 2011;2011. doi: 10.1155/2011/378268. Epub 2010 Aug 10.
本文引用的文献
1
Lipid synthesis in peripheral nerve from alloxan diabetic rats.四氧嘧啶糖尿病大鼠周围神经中的脂质合成
Lipids. 1966 Jul;1(4):237-40. doi: 10.1007/BF02531608.
2
'Phosphatido-peptide'-like complexes formed by the interaction of calcium triphosphoinositide with protein.由三磷酸肌醇钙与蛋白质相互作用形成的“磷脂肽”样复合物。
Biochem J. 1965 Oct;97(1):134-8. doi: 10.1042/bj0970134.
3
NERVE CONDUCTION CHANGES IN EXPERIMENTAL DIABETES.实验性糖尿病中的神经传导变化
J Clin Invest. 1964 Dec;43(12):2353-8. doi: 10.1172/JCI105109.
4
QUANTITATIVE ANALYSIS OF SERUM AND URINE SUGARS BY GAS CHROMATOGRAPHY.气相色谱法对血清和尿液糖分的定量分析
Clin Chim Acta. 1964 Oct;10:352-9. doi: 10.1016/0009-8981(64)90066-x.
5
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
6
The formation of free and lipid myo-inositol in the intact rat.完整大鼠体内游离型和脂质型肌醇的形成
Biochim Biophys Acta. 1963 Jun 18;70:278-89. doi: 10.1016/0006-3002(63)90752-2.
7
Polyol accumulations in nervous tissue of rats with experimental diabetes and galactosaemia.实验性糖尿病和半乳糖血症大鼠神经组织中的多元醇蓄积
J Neurochem. 1967 Nov;14(11):1057-66. doi: 10.1111/j.1471-4159.1967.tb09516.x.
8
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.山梨醇途径：存在于神经和脊髓中，在糖尿病时会有底物蓄积。
Science. 1966 Jan 14;151(3707):209-10. doi: 10.1126/science.151.3707.209.
9
Substrate changes in peripheral nerve during ischaemia and Wallerian degeneration.缺血和沃勒变性过程中周围神经的底物变化。
J Neurochem. 1965 Aug;12(8):719-27. doi: 10.1111/j.1471-4159.1965.tb06786.x.
10
Alloxan induced neuropathies: lipid changes in nerve and root fragments.四氧嘧啶诱发的神经病变：神经和神经根片段中的脂质变化。
Life Sci. 1969 May 1;8(9):493-8. doi: 10.1016/0024-3205(69)90442-1.
Zotero 插件