Salzberg Trang N, Overstreet Benjamin T, Rogers Jeffrey D, Califano Joseph V, Best Al M, Schenkein Harvey A
Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, 23298-0566, USA.
J Periodontol. 2006 Jun;77(6):933-9. doi: 10.1902/jop.2006.050165.
Sera from patients with periodontal infections contain elevated levels of C-reactive protein (CRP) compared to periodontally healthy individuals. Most studies to date have included patients with chronic periodontitis, and few investigators have studied CRP levels in subjects with aggressive periodontitis (AgP). The purpose of this study was to determine the relative levels of serum CRP in AgP patients and periodontally healthy subjects and to examine patients' characteristics that might account for intergroup differences.
Serum samples were collected from 93 patients with generalized AgP (GAgP), from 97 patients with localized AgP (LAgP), and from 91 healthy controls (non-periodontitis [NP]). Periodontal examination consisted of plaque index, gingival index, probing depth, bleeding index, and attachment loss measurements. Current smoking was assessed by determination of serum cotinine levels by enzyme-linked immunosorbent assay (ELISA), and serum CRP levels were determined using a high-sensitivity ELISA assay.
The three groups were significantly different from one another (P <0.0001). The 95% confidence interval for serum CRP concentrations were as follows: NP, 0.65919 (0.4901 to 0.8869); LAgP, 1.10138 (0.8265 to 1.468); and GAgP, 2.05318 (1.5313 to 2.7538) mg/l. CRP levels in both LAgP and GAgP subjects were significantly greater than those in NP subjects, and levels in GAgP were significantly greater than those in LAgP. Following adjustment of the data for periodontal and demographic variables and current smoking, both mean probing depth and periodontal diagnosis remained correlated with CRP levels.
Patients with AgP have statistically significant elevations in serum CRP levels compared to subjects without periodontitis. Elevated CRP in these subjects might represent a contribution of periodontal infections to systemic inflammation in relatively young individuals.
与牙周健康个体相比，牙周感染患者血清中的C反应蛋白（CRP）水平升高。迄今为止，大多数研究纳入的是慢性牙周炎患者，很少有研究者研究侵袭性牙周炎（AgP）患者的CRP水平。本研究的目的是确定AgP患者和牙周健康受试者血清CRP的相对水平，并检查可能导致组间差异的患者特征。
收集了93例广泛型AgP（GAgP）患者、97例局限型AgP（LAgP）患者和91例健康对照者（非牙周炎[NP]）的血清样本。牙周检查包括菌斑指数、牙龈指数、探诊深度、出血指数和附着丧失测量。通过酶联免疫吸附测定（ELISA）法测定血清可替宁水平来评估当前吸烟情况，并使用高灵敏度ELISA法测定血清CRP水平。
三组之间存在显著差异（P<0.0001）。血清CRP浓度的95%置信区间如下：NP组为0.65919（0.4901至0.8869）；LAgP组为1.10138（0.8265至1.468）；GAgP组为2.05318（1.5313至2.7538）mg/l。LAgP组和GAgP组受试者的CRP水平均显著高于NP组受试者，且GAgP组的水平显著高于LAgP组。在对牙周和人口统计学变量以及当前吸烟情况的数据进行调整后，平均探诊深度和牙周诊断仍与CRP水平相关。
与无牙周炎的受试者相比，AgP患者的血清CRP水平在统计学上显著升高。这些受试者中CRP升高可能代表牙周感染对相对年轻个体全身炎症有影响。
