Andriankaja Oelisoa M, Genco Robert J, Dorn Joan, Dmochowski Jacek, Hovey Kathy, Falkner Karen L, Scannapieco Frank, Trevisan Maurizio
School of Public Health and Health Professions, University at Buffalo, NY 14214, USA.
J Periodontol. 2006 Jun;77(6):1067-73. doi: 10.1902/jop.2006.050276.
The role of periodontal disease as an independent risk factor for cardiovascular disease (CVD) has been under debate because of the inconsistency of findings across studies. One of the major issues is the method used to assess or define periodontal disease. The present study assesses if the observed association between periodontal disease and incident myocardial infarction (MI) depends on the measurements and/or criteria used to define periodontal disease.
A population-based case-control study to evaluate the association between PD and risk of MI was conducted between 1997 and 2001 in Western New York with 537 cases and 800 controls, aged 35 to 69 years. Cases were survivors of incident MI from local hospitals in Erie and Niagara counties. Controls were randomly selected from residents of the same counties. Periodontal disease was assessed using interproximal clinical attachment loss (CAL), probing depth (PD), alveolar crest height (ACH), and number of missing teeth. From these measurements, four different case definitions of periodontal disease were created.
Using the continuous forms of periodontal measurements, the odds ratios (ORs) (95% confidence interval) of the association with incident MI were 1.46 (1.26 to 1.69), 2.19 (1.66 to 2.89), 1.30 (1.14 to 1.49), and 1.04 (1.02 to 1.07) for mean CAL, PD, ACH, and number of missing teeth, respectively. Regardless of the case definition of periodontal disease, the estimates of the association with incident MI were statistically significant.
The observed association between periodontal disease and incident MI was consistent across different measurements and/or case definitions of periodontal disease used. The magnitude of the association varies depending on the measurements or the criteria used to define periodontal disease.
由于各项研究结果不一致，牙周病作为心血管疾病（CVD）独立危险因素的作用一直存在争议。主要问题之一是用于评估或定义牙周病的方法。本研究评估牙周病与新发心肌梗死（MI）之间观察到的关联是否取决于用于定义牙周病的测量方法和/或标准。
1997年至2001年在纽约西部进行了一项基于人群的病例对照研究，以评估牙周病与MI风险之间的关联，研究对象为537例病例和800例对照，年龄在35至69岁之间。病例为伊利和尼亚加拉县当地医院新发MI的幸存者。对照从同一县的居民中随机选取。使用邻面临床附着丧失（CAL）、探诊深度（PD）、牙槽嵴高度（ACH）和缺失牙数量评估牙周病。根据这些测量结果，创建了四种不同的牙周病病例定义。
使用牙周测量的连续形式，平均CAL、PD、ACH和缺失牙数量与新发MI关联的比值比（OR）（95%置信区间）分别为1.46（1.26至1.69）、2.19（1.66至2.89）、1.30（1.14至1.49）和1.04（1.02至1.07）。无论牙周病的病例定义如何，与新发MI关联的估计值均具有统计学意义。
在使用的不同牙周病测量方法和/或病例定义中，牙周病与新发MI之间观察到的关联是一致的。关联的程度因用于定义牙周病的测量方法或标准而异。
