Kodovazenitis G, Pitsavos C, Papadimitriou L, Vrotsos I A, Stefanadis C, Madianos P N
Department of Periodontology, School of Dentistry, University of Athens, Athens, Greece.
J Periodontal Res. 2014 Apr;49(2):246-52. doi: 10.1111/jre.12101. Epub 2013 May 29.
Periodontitis and acute myocardial infarction (AMI) are two diseases that share common risk factors. The role of periodontitis as an independent risk factor for cardiovascular disease has been under debate. The aim of this study was to investigate whether an association exists between periodontitis and AMI in a nondiabetic population, using multiple periodontal case definitions.
Periodontal examination was performed in 204 patients with AMI. The control group comprised 102 healthy subjects, without significant coronary disease, confirmed angiographically. Periodontitis was assessed using measurements of clinical attachment loss (CAL), probing depth and number of missing teeth. From these measurements, five different case definitions of periodontitis were generated.
Using the continuous forms of periodontal measurements, the odds ratio (95% confidence interval) of the association with incident AMI was 1.74 (1.26-2.50), 1.83 (1.10-3.17) and 1.08 (1.06-1.13) for mean CAL, probing depth and number of missing teeth, respectively. A consistent positive association was observed regardless of the case definition of periodontitis.
In this nondiabetic population, the association between periodontitis and AMI was consistent across different measurements and/or definitions of periodontitis. The strength of the association increased concomitantly with the robustness of the criteria used to define periodontitis.
牙周炎和急性心肌梗死（AMI）是两种具有共同危险因素的疾病。牙周炎作为心血管疾病独立危险因素的作用一直存在争议。本研究的目的是使用多种牙周病例定义，调查在非糖尿病人群中牙周炎与AMI之间是否存在关联。
对204例AMI患者进行了牙周检查。对照组包括102名经血管造影证实无明显冠心病的健康受试者。使用临床附着丧失（CAL）、探诊深度和缺失牙数的测量来评估牙周炎。根据这些测量结果，生成了五种不同的牙周炎病例定义。
使用牙周测量的连续形式，平均CAL、探诊深度和缺失牙数与新发AMI关联的比值比（95%置信区间）分别为1.74（1.26 - 2.50）、1.83（1.10 - 3.17）和1.08（1.06 - 1.13）。无论牙周炎的病例定义如何，均观察到一致的正相关。
在这个非糖尿病人群中，牙周炎与AMI之间的关联在不同的牙周测量和/或定义中是一致的。关联强度随着用于定义牙周炎的标准的稳健性而相应增加。
