Andriankaja Oelisoa Mireille, Genco Robert J, Dorn Joan, Dmochowski Jacek, Hovey Kathy, Falkner Karen L, Trevisan Maurizio
Social and Preventive Medicine, SUNY at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA.
Eur J Epidemiol. 2007;22(10):699-705. doi: 10.1007/s10654-007-9166-6. Epub 2007 Sep 8.
Studies examining the association between periodontal disease and coronary heart disease have shown a consistent but weak to moderate relationship. Limited data have been reported in women and the role of smoking has not been fully clarified.
METHODS/RESULTS: A population-based case-control study examining the association between periodontal disease (PD) and acute non-fatal myocardial infarction (MI) was conducted in Erie and Niagara counties in Western New York State. Cases (574) were discharged alive from local hospitals with MI diagnosis. Controls (887) were county residents randomly selected from the NY State Department of Motor Vehicles rolls and Health Care Financing Administration files. Periodontal disease was assessed using clinical attachment loss (CAL). Among men (415 cases), the odds ratio (OR) of the association between mean CAL (mm) and MI, adjusting for the effects of age, body mass index (BMI), physical activity, hypertension, cholesterol, diabetes, and total pack-years of cigarette smoking was 1.34 (1.15-1.57). In women (120 cases), the corresponding OR was 2.08 (1.47-2.94). The estimate of this association among non-smokers, also adjusting for age, gender, BMI, physical activity, hypertension, cholesterol, diabetes, and total pack-years of cigarette smoking, was 1.40 (1.06-1.86), while it was 1.49 (1.26-1.77) among smokers.
This study provides evidence of an association between PD and incident MI in both genders. This association appears to be independent from the possible confounding effect of smoking.
关于牙周疾病与冠心病之间关联的研究显示出一种持续但较弱至中等强度的关系。关于女性的相关数据报道有限，且吸烟的作用尚未完全阐明。
方法/结果：在纽约州西部的伊利县和尼亚加拉县开展了一项基于人群的病例对照研究，以检验牙周疾病（PD）与急性非致死性心肌梗死（MI）之间的关联。病例组（574例）为从当地医院确诊为MI且存活出院的患者。对照组（887例）是从纽约州机动车管理局名册和医疗保健财务管理局档案中随机选取的该县居民。使用临床附着丧失（CAL）评估牙周疾病。在男性（415例病例）中，校正年龄、体重指数（BMI）、身体活动、高血压、胆固醇、糖尿病和吸烟总包年数的影响后，平均CAL（mm）与MI之间关联的比值比（OR）为1.34（1.15 - 1.57）。在女性（120例病例）中，相应的OR为2.08（1.47 - 2.94）。在非吸烟者中，校正年龄、性别、BMI、身体活动、高血压、胆固醇、糖尿病和吸烟总包年数后，该关联的估计值为1.40（1.06 - 1.86），而在吸烟者中为1.49（1.26 - 1.77）。
本研究提供了PD与两性新发MI之间存在关联的证据。这种关联似乎独立于吸烟可能产生的混杂效应。
