Stock C, Schwab A
Institute of Physiology II, University of Münster, Münster, Germany.
Acta Physiol (Oxf). 2006 May-Jun;187(1-2):149-57. doi: 10.1111/j.1748-1716.2006.01543.x.
Cell migration plays a basic role in many physiological and pathophysiological processes such as embryogenesis, immune defence, wound healing or metastasis. The activity of the ubiquitously expressed NHE1 isoform of the plasma membrane Na+/H+ exchanger is one of the requirements for directed locomotion of migrating cells and also contributes to cell adhesion. The mechanisms by which NHE1 is involved in cell migration are multiple. NHE1 contributes to cell migration by affecting the cell volume, by regulating the intracellular pH and thereby the assembly and activity of cytoskeletal elements, by anchoring the cytoskeleton to the plasma membrane, by signalling, by regulating gene expression and by controlling cell adhesion. The present article gives a review of the different ways in which NHE1 is involved in and contributes to cell migration. These different mechanisms complement one another forming an intricate, integrative process.
细胞迁移在许多生理和病理生理过程中发挥着基本作用，如胚胎发育、免疫防御、伤口愈合或转移。质膜钠/氢交换体普遍表达的NHE1亚型的活性是迁移细胞定向运动的必要条件之一，也有助于细胞黏附。NHE1参与细胞迁移的机制是多方面的。NHE1通过影响细胞体积、调节细胞内pH值从而影响细胞骨架成分的组装和活性、将细胞骨架锚定到质膜、信号传导、调节基因表达以及控制细胞黏附等方式促进细胞迁移。本文综述了NHE1参与并促进细胞迁移的不同方式。这些不同机制相互补充，形成一个复杂的整合过程。
