Angst Jules, Gamma Alex, Joseph Bienvenu O, Eaton William W, Ajdacic Vladeta, Eich Dominique, Rössler Wulf
Zurich University Psychiatric Hospital, Zurich, Switzerland.
Psychol Med. 2006 Sep;36(9):1283-92. doi: 10.1017/S0033291706007938. Epub 2006 May 31.
This study questions the 6-month duration criterion for generalized anxiety disorder (GAD) used in DSM-III-R and DSM-IV.
In adults from age 20/21 to 40/41 in the prospective Zurich Cohort Study, four groups of generalized anxiety syndromes defined by varying duration (2 weeks, 1 month, 3 months and 6 months) were compared.
Applying DSM-III (1979-1999) and DSM-III-R (1986-1999) criteria, there were no significant differences between the four groups in terms of family history of anxiety, work impairment, distress, treatment rates or co-morbidity with major depressive episodes (MDEs), bipolar disorder or suicide attempts. Only social impairment related to the length of episodes. The 6-month criterion of DSM-III-R and DSM-IV GAD would preclude this diagnosis in about half of the subjects treated for generalized anxiety syndromes.
In this epidemiological sample, the 6-month duration criterion for GAD could not be confirmed as clinically meaningful. GAD syndromes of varying duration form a continuum with comparable clinical relevance.
本研究对《精神疾病诊断与统计手册》第三版修订本(DSM-III-R)和第四版(DSM-IV)中用于广泛性焦虑障碍(GAD)的6个月病程标准提出质疑。
在苏黎世前瞻性队列研究中,对年龄在20/21岁至40/41岁的成年人,比较了四组由不同病程(2周、1个月、3个月和6个月)定义的广泛性焦虑综合征。
应用DSM-III(1979 - 1999年)和DSM-III-R(1986 - 1999年)标准,四组在焦虑家族史、工作受损情况、痛苦程度、治疗率或与重度抑郁发作(MDEs)、双相情感障碍或自杀未遂的共病情况方面无显著差异。只有社会功能受损与发作时长有关。DSM-III-R和DSM-IV中GAD的6个月病程标准会使约一半接受广泛性焦虑综合征治疗的受试者无法得到该诊断。
在这个流行病学样本中,GAD的6个月病程标准无法被确认为具有临床意义。不同病程的GAD综合征构成一个具有相当临床相关性的连续体。