Kohli Rakhi, Klein Robert S, Schoenbaum Ellie E, Anastos Kathryn, Minkoff Howard, Sacks Henry S
Division of Geographic Medicine and Infectious Disease, Department of Medicine, Tufts-New England Medical Center, 750 Washington Street #41, Boston, MA 02111, USA.
J Urban Health. 2006 Jan;83(1):31-42. doi: 10.1007/s11524-005-9005-6.
With the advent of highly active antiretroviral therapy (HAART) in mid-1995, the prognosis for HIV-infected individuals has brightened dramatically. However, the conjunction of potent antiviral therapy and longer life expectancy may engender a variety of health risks that, heretofore, HIV specialists have not had to confront. The long-term effects of HIV infection itself and exposure to antiretroviral agents is unknown. Several aspects of aging, including psychiatric disease, neurocognitive impairment, and metabolic and hormonal disorders, may be influenced by chronic exposure to HIV and/or HIV therapeutics. In this paper, we discuss the health issues confronting HIV-infected older adults and areas for future research.
随着1995年年中高效抗逆转录病毒疗法（HAART）的出现，HIV感染者的预后显著改善。然而，强效抗病毒疗法与更长的预期寿命相结合，可能会引发各种健康风险，而这些风险是迄今为止HIV专家无需面对的。HIV感染本身以及接触抗逆转录病毒药物的长期影响尚不清楚。衰老的几个方面，包括精神疾病、神经认知障碍以及代谢和激素紊乱，可能会受到长期接触HIV和/或HIV治疗药物的影响。在本文中，我们讨论了HIV感染的老年成年人面临的健康问题以及未来的研究领域。
