New coupling reaction of secondary amines, aldehydes, and alkynes catalyzed by an iridium complex.
作者信息
Sakaguchi Satoshi, Mizuta Tomoya, Ishii Yasutaka
机构信息
Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan.
出版信息
Org Lett. 2006 Jun 8;8(12):2459-62. doi: 10.1021/ol060578z.
PMID:16737288
Abstract
A new reductive coupling reaction of secondary amines, aldehydes, and alkynes using an iridium complex as catalyst has been developed. For example, dibutylamine was allowed to react with butyraldehyde and 1-octyne in 1,4-dioxane at 50 degrees C under the influence of a catalytic amount of IrCl(cod) to give the corresponding allylamines such as N,N-dibutyl-2-butylideneoctylamine and N,N-2-tributyl-2-octenylamine in excellent yields. [reaction: see text]
摘要
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