Cho Ji Young, Kwon Hak Cheol, Williams Philip G, Jensen Paul R, Fenical William
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.
Org Lett. 2006 Jun 8;8(12):2471-4. doi: 10.1021/ol060630r.
A novel meroterpenoid, azamerone, was isolated from the saline culture of a new marine-derived bacterium related to the genus Streptomyces. Azamerone is composed of an unprecedented chloropyranophthalazinone core with a 3-chloro-6-hydroxy-2,2,6-trimethylcyclohexylmethyl side chain. The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed. [structure: see text]
从一种与链霉菌属相关的新型海洋来源细菌的盐培养物中分离出一种新型半萜类化合物——氮杂美罗酮。氮杂美罗酮由一个前所未有的氯代吡喃并酞嗪酮核心和一个3-氯-6-羟基-2,2,6-三甲基环己基甲基侧链组成。通过核磁共振光谱和X射线晶体学严格确定了其结构。提出了这种不寻常环系可能的生物合成起源。[结构：见原文]
