The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, ‡School of Enology, and §School of Gerontology, Binzhou Medical University , Yantai 264003, China.
Org Lett. 2016 Mar 18;18(6):1402-5. doi: 10.1021/acs.orglett.6b00332. Epub 2016 Mar 9.
Grisemycin (1), the first sulfur angucyclinone with an unusual ether-bridged system, was isolated from a marine-derived Streptomyces griseus strain M268. Its novel, here cage-like, structure was determined by spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited modestly selective activity against the HL-60 cell line with an IC50 value of 31.54 μM. Futhermore, the absolute stereochemistry of kiamycin (2), an 1,12-epoxybenz[a]anthracene, previously obtained from the same strain, was established by X-ray diffraction analysis.
灰霉素（1）是第一个具有不寻常的醚桥系统的硫氮杂环庚酮，从海洋来源的链霉菌 M268 中分离得到。其新颖的笼状结构通过光谱分析和单晶 X 射线衍射确定。化合物 1 对 HL-60 细胞系表现出适度的选择性活性，IC50 值为 31.54 μM。此外，先前从同一菌株中获得的 1,12-环氧苯[a]蒽霉素（2）的绝对立体化学结构通过 X 射线衍射分析确定。
