Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California , San Diego, La Jolla, California 92093-0204, United States.
Org Lett. 2013 Nov 1;15(21):5400-3. doi: 10.1021/ol402080s. Epub 2013 Oct 23.
The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50 = 2.0 μg/mL.
本文报道了一种新型的混合倍半萜，放线诺酮（1），由一种与链霉菌属密切相关的海洋细菌产生。放线诺酮由一个前所未有的二氢萘酮聚酮与一个双环二萜连接而成。通过应用先进的莫斯尔法和对光谱数据的解释，确定了 1 的立体化学。放线诺酮（1）对 HCT-116 人结肠癌细胞具有显著的细胞毒性，LD50 = 2.0 μg/mL。
