Nibau Candida, Wu Hen-ming, Cheung Alice Y
Plant Biology Graduate Program, University of Massachusetts, Lederle Graduate Research Tower, Department of Biochemistry and Molecular Biology, Amherst, MA 10003, USA.
Trends Plant Sci. 2006 Jun;11(6):309-15. doi: 10.1016/j.tplants.2006.04.003. Epub 2006 Jun 5.
RAC/ROP GTPases are a family of plant-specific signaling molecules solely representing the Ras and Rho family of Ras-related G proteins in plants. RAC/ROPs potentially interact with cell surface-associated signal perception apparatus for a broad range of extracellular stimuli, including hormones, pathogen elicitors and abiotic stress, and mediate diverse cellular pathways in response to these signals. They are also known to interact with multiple effectors, affecting cellular and biochemical systems that regulate actin dynamics, reactive oxygen species production, proteolysis, and gene expression. RAC/ROPs are, thus, ideally suited as integrators for multiple signals and as coordinators of diverse cellular pathways to control growth, differentiation, development and defense responses. Recent findings that suggest how RAC/ROP signaling activity is regulated and how functional specificity can be achieved are discussed here.
RAC/ROP GTP酶是植物特有的信号分子家族，在植物中仅代表与Ras相关的G蛋白的Ras和Rho家族。RAC/ROP可能与细胞表面相关的信号感知装置相互作用，以应对广泛的细胞外刺激，包括激素、病原体激发子和非生物胁迫，并介导响应这些信号的多种细胞途径。它们还已知与多种效应器相互作用，影响调节肌动蛋白动力学、活性氧产生、蛋白水解和基因表达的细胞和生化系统。因此，RAC/ROP非常适合作为多种信号的整合器和多种细胞途径的协调器，以控制生长、分化、发育和防御反应。本文讨论了最近关于RAC/ROP信号活性如何被调节以及如何实现功能特异性的研究发现。
