Wehr H, Czartoryska B, Górska D, Matsumoto H
Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland.
Alcohol Clin Exp Res. 1991 Feb;15(1):13-5. doi: 10.1111/j.1530-0277.1991.tb00513.x.
In 25-alcohol-dependent patients in whom detoxication treatment has been introduced serum total beta-hexosaminidase, thermostable beta-hexosaminidase, alpha-mannosidase and gamma glutamylotransferase (GGT) and serum high density lipoprotein (HDL) cholesterol were determined during alcohol withdrawal. The assays were also performed in a group of dependent individuals after a 1 month or longer period of abstinence. Marked increase in beta-hexosaminidase activity was observed in intoxicated patients. The activity decreased rapidly after the cessation of drinking, resembling the decrease in HDL cholesterol level in its dynamics. The alpha-mannosidase activity rise was less pronounced and its normalization was slow, similar to the GGT activity normalization rate. The rise of beta-hexosaminidase activity was mostly due to the thermostable component of the enzyme. Total beta-hexosaminidase or thermostable beta-hexosaminidase activity determinations appear to be simple and reliable markers of alcohol abuse.
在25例接受脱毒治疗的酒精依赖患者中，在酒精戒断期间测定了血清总β-己糖胺酶、耐热β-己糖胺酶、α-甘露糖苷酶和γ-谷氨酰转移酶（GGT）以及血清高密度脂蛋白（HDL）胆固醇。在一组依赖个体戒酒1个月或更长时间后也进行了检测。在醉酒患者中观察到β-己糖胺酶活性显著增加。停止饮酒后，其活性迅速下降，在动态变化上类似于HDL胆固醇水平的下降。α-甘露糖苷酶活性的升高不太明显，其恢复正常的速度较慢，类似于GGT活性恢复正常的速度。β-己糖胺酶活性的升高主要归因于该酶的耐热成分。总β-己糖胺酶或耐热β-己糖胺酶活性测定似乎是酒精滥用的简单可靠标志物。
