Hultberg B, Isaksson A, Berglund M, Moberg A L
Department of Clinical Chemistry, University Hospital, Lund, Sweden.
Alcohol Clin Exp Res. 1991 Jun;15(3):549-52. doi: 10.1111/j.1530-0277.1991.tb00558.x.
Serum beta-hexosaminidase (Hex) isoenzymes analyzed by enzyme immunoassay were investigated in a group of alcoholics (n = 38) hospitalized for detoxication, in another group of alcoholics (n = 22) abstinent between 6 days and 10 years and in a reference group (n = 20). Hex "B" isoenzyme was elevated in all 38 patients hospitalized for detoxication but only 35 of these had total Hex values above the upper limit of the reference group. The Hex A isoenzyme, gamma-glutamyltransferase, and aspartate aminotransferase showed considerable overlap between these patients and the reference group. In the group of 22 abstinent patients only one had an increased level of Hex A, Hex "B," and total Hex, whereas 10 had gamma-glutamyltransferase values above the upper limit of the reference group. It is concluded that Hex "B" is a useful marker for alcohol abuse.
通过酶免疫测定法分析血清β - 己糖胺酶（Hex）同工酶，对一组因解毒而住院的酗酒者（n = 38）、另一组戒酒6天至10年的酗酒者（n = 22）以及一个参照组（n = 20）进行了研究。在所有38名因解毒而住院的患者中，Hex “B” 同工酶升高，但其中只有35人的总Hex值高于参照组上限。Hex A同工酶、γ - 谷氨酰转移酶和天冬氨酸氨基转移酶在这些患者与参照组之间有相当大的重叠。在22名戒酒患者组中，只有1人Hex A、Hex “B” 和总Hex水平升高，而有10人的γ - 谷氨酰转移酶值高于参照组上限。得出的结论是，Hex “B” 是酒精滥用的一个有用标志物。
