Hultberg B, Isaksson A, Berglund M, Alling C
Department of Clinical Chemistry, University Hospital, Lund, Sweden.
Alcohol Clin Exp Res. 1995 Apr;19(2):452-6. doi: 10.1111/j.1530-0277.1995.tb01530.x.
beta-Hexosaminidase B-isoforms (beta-hexosaminidase B, P, and intermediate forms; abbreviated herein as "Hex B") and serum carbohydrate-deficient transferrin (CDT) are two markers of alcohol abuse. In the present study, we have compared "Hex B" with CDT as markers of alcohol abuse in a group of alcoholics hospitalized for detoxification after a period of heavy alcohol abuse. We have also followed the disappearance rate of these two markers from circulation. "Hex B" was elevated in 38 of 42 patients hospitalized for detoxication, whereas CDT was elevated in 35 of 42 patients. A highly significant correlation was noted between "Hex B" and CDT in these patients (p = 0.52, p < 0.001). Neither "Hex B" nor CDT correlated with gamma-glutamyltransferase or AST. The disappearance rates from serum of "Hex B" and CDT were determined in 21 hospitalized patients followed for up to 15 days. "Hex B" and CDT showed similar time-course variation and half-lives, 6.5 +/- 3.7 (mean +/- SD) and 8.6 +/- 4.1 days, respectively. The possible reasons for a relation between these two markers are discussed, and it is concluded that more experience of both "Hex B" and CDT in unselected populations is needed to establish the diagnostic potential of these tests as markers of alcohol abuse.
β-己糖胺酶B同工型（β-己糖胺酶B、P及其中间形式；本文简称为“己糖胺酶B”）和血清缺糖转铁蛋白（CDT）是酒精滥用的两项标志物。在本研究中，我们在一组因长期大量饮酒后住院进行解毒治疗的酗酒者中，比较了“己糖胺酶B”和CDT作为酒精滥用标志物的情况。我们还追踪了这两种标志物从循环系统中消失的速率。42例住院进行解毒治疗的患者中，38例“己糖胺酶B”升高，而42例患者中有35例CDT升高。在这些患者中，“己糖胺酶B”与CDT之间存在高度显著的相关性（p = 0.52，p < 0.001）。“己糖胺酶B”和CDT均与γ-谷氨酰转移酶或谷草转氨酶无相关性。在21例住院患者中测定了“己糖胺酶B”和CDT从血清中的消失速率，追踪时间长达15天。“己糖胺酶B”和CDT显示出相似的时间进程变化和半衰期，分别为6.5±3.7（均值±标准差）天和8.6±4.1天。讨论了这两种标志物之间存在关联的可能原因，并得出结论，需要在未经过筛选的人群中对“己糖胺酶B”和CDT有更多经验，才能确定这些检测作为酒精滥用标志物的诊断潜力。
