Kelley George A, Kelley Kristi S, Franklin Barry
Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, 26506-9190, USA.
J Cardiopulm Rehabil. 2006 May-Jun;26(3):131-9; quiz 140-1, discussion 142-4. doi: 10.1097/00008483-200605000-00002.
Use the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults with cardiovascular disease (CVD).
Studies were retrieved via electronic databases, review of reference lists from retrieved articles, including reviews, and hand searching. Inclusion criteria were: (1) randomized controlled trials, (2) aerobic exercise >or=4 weeks as an intervention, (3) studies published in English language only between January 1, 1955 and January 1, 2005, (4) studies published in journals or as dissertations or master's theses, (5) human subjects >or=18 years, (6) all subjects diagnosed with some type of CVD, and (7) pre and post data available for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). Random-effects models were used for data analysis.
Of the more than 3,000 studies reviewed, a total of 10 representing 1,260 subjects (580 exercise, 680 control) were included in our analysis. There was a statistically significant increase of 9% in HDL-C (mean +/- SEM, 3.7 +/- 1.3 mg/dL; 95% CI, 1.2 to 6.1 mg/dL) and a statistically significant decrease of 11% in TG (-19.3 +/- 5.4 mg/dL; 95% CI, -30.1 to -8.5 mg/dL), but no statistically significant decreases in TC or LDL-C (TC, -8.8 +/- 6.8 mg/dL; 95% CI, -22.3 to 4.7 mg/dL; LDL-C, -7.7 +/- 6.0 mg/dL; 95% CI, -19.5 to 4.2 mg/dL).
The present findings suggest that chronic aerobic exercise increases HDL-C and decreases TG in adults, especially men, with CVD.
采用荟萃分析方法研究有氧运动对成年心血管疾病（CVD）患者血脂和脂蛋白的影响。
通过电子数据库检索研究，查阅检索文章的参考文献列表（包括综述），并进行手工检索。纳入标准为：（1）随机对照试验；（2）有氧运动干预时长≥4周；（3）仅纳入1955年1月1日至2005年1月1日期间发表的英文研究；（4）发表于期刊、博士论文或硕士论文的研究；（5）受试者年龄≥18岁；（6）所有受试者均被诊断患有某种类型的CVD；（7）可获取总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和/或甘油三酯（TG）的前后数据。采用随机效应模型进行数据分析。
在检索的3000多项研究中，共有10项研究（代表1260名受试者，其中580名运动组，680名对照组）纳入我们的分析。HDL-C有统计学意义的升高9%（均值±标准误，3.7±1.3mg/dL；95%可信区间，1.2至6.1mg/dL），TG有统计学意义的降低11%（-19.3±5.4mg/dL；95%可信区间，-30.1至-8.5mg/dL），但TC或LDL-C无统计学意义的降低（TC，-8.8±6.8mg/dL；95%可信区间，-22.3至4.7mg/dL；LDL-C，-7.7±6.0mg/dL；95%可信区间，-19.5至4.2mg/dL）。
目前的研究结果表明，长期有氧运动可使成年CVD患者，尤其是男性患者的HDL-C升高，TG降低。
