有氧运动对2型糖尿病成人患者血脂和脂蛋白的影响：一项随机对照试验的荟萃分析
Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials.
作者信息
Kelley G A, Kelley K S
机构信息
School of Medicine, Department of Community Medicine, West Virginia University, P.O. Box 9190, Morgantown, WV, USA.
出版信息
Public Health. 2007 Sep;121(9):643-55. doi: 10.1016/j.puhe.2007.02.014. Epub 2007 Jun 1.
OBJECTIVE
To conduct a meta-analysis of randomized-controlled trials in order to examine the effects of 8 weeks or more of aerobic exercise on lipids and lipoproteins in adults with Type 2 diabetes.
METHODS
Studies were included if total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), ratio of TC to HDL-C (TC/HDL-C), triglycerides (TG), or all of the above, were assessed. A secondary outcome was glycosylated haemoglobin (HbA1).
RESULTS
Seven studies representing 220 men and women (112 exercise, 108 control) were available for pooling. Using a random-effects model, a statistically significant reduction of about 5% was found for LDL-C, whereas no statistically significant improvements were found for TC, HDL-C, TC/HDL-C or TG. A trend for a statistically significant reduction in HbA1 was also found.
CONCLUSIONS
Although our overall results suggest that aerobic exercise lowers LDL-C in adults with Type 2 diabetes, additional randomized-controlled trials are needed on this topic.
目的
进行一项随机对照试验的荟萃分析，以研究8周或更长时间的有氧运动对2型糖尿病成年人血脂和脂蛋白的影响。
方法
纳入评估总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、TC与HDL-C之比（TC/HDL-C）、甘油三酯（TG）或以上所有指标的研究。次要结局指标为糖化血红蛋白（HbA1）。
结果
共有7项研究，涉及220名男性和女性（112名运动组，108名对照组）可供汇总分析。采用随机效应模型，发现LDL-C有统计学意义的约5%的降低，而TC、HDL-C、TC/HDL-C或TG未发现有统计学意义的改善。还发现HbA1有统计学意义降低的趋势。
结论
尽管我们的总体结果表明有氧运动可降低2型糖尿病成年人的LDL-C，但关于该主题仍需要更多的随机对照试验。
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