请稍等——下一个可用的外显子马上就来。

Please hold--the next available exon will be right with you.

作者信息

Neugebauer Karla M

出版信息

Nat Struct Mol Biol. 2006 May;13(5):385-6. doi: 10.1038/nsmb0506-385.

Abstract

A major challenge in gene expression is to understand how precursor messenger RNA (pre-mRNA) processing events are integrated with transcription. A recent study suggests that distant exons in nascent RNA are held together during transcription, promoting accurate splicing independent of intron fate.

摘要

基因表达中的一个主要挑战是理解前体信使核糖核酸（pre-mRNA）加工事件是如何与转录整合的。最近的一项研究表明，新生RNA中的远距离外显子在转录过程中会聚集在一起，从而促进精确剪接，而这一过程与内含子的命运无关。