Parent Amélie, Bisaillon Martin
Département de Biochimie, Faculté de Médecine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec, J1H 5N4 Canada.
Med Sci (Paris). 2006 Jun-Jul;22(6-7):626-32. doi: 10.1051/medsci/20062267626.
Processing of eukaryotic pre-mRNAs is an important step for the translation of proteins. These processing events include the addition of a cap structure at the 5' terminus of the pre-mRNA, the splicing out of introns and the acquisition of a polyadenosine tail at the 3' terminus of the pre-mRNA. It has now become apparent that the RNA processing events can significantly influence each other. RNA polymerase II appears as a key player in these processes, cooperating with numerous processing factors that are involved in capping, splicing, and polyadenylation. More specifically, the carboxyterminal domain of the large subunit of the enzyme plays a critical role in coordination of the processing events. The number of interactions between the various RNA processing events identified so far reflects the complexity of these reactions. As more studies focus on these interactions, additional links and cellular partners will undoubtedly be discovered.
真核生物前体mRNA的加工是蛋白质翻译的重要步骤。这些加工事件包括在前体mRNA的5'末端添加帽结构、去除内含子以及在前体mRNA的3'末端获得聚腺苷酸尾巴。现在已经很明显，RNA加工事件之间会相互产生显著影响。RNA聚合酶II似乎是这些过程中的关键参与者，它与众多参与加帽、剪接和聚腺苷酸化的加工因子协同作用。更具体地说，该酶大亚基的羧基末端结构域在协调加工事件中起着关键作用。目前已确定的各种RNA加工事件之间的相互作用数量反映了这些反应的复杂性。随着更多研究聚焦于这些相互作用，无疑会发现更多的联系和细胞伙伴。
