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UCHL1+（CD45RO+）“记忆”T细胞在特应性个体中与变应原诱导的迟发性皮肤反应相关的CD4+细胞浸润中占主导地位。

UCHL1+ (CD45RO+) 'memory' T cells predominate in the CD4+ cellular infiltrate associated with allergen-induced late-phase skin reactions in atopic subjects.

作者信息

Frew A J, Kay A B

机构信息

Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, England.

出版信息

Clin Exp Immunol. 1991 May;84(2):270-4. doi: 10.1111/j.1365-2249.1991.tb08160.x.

DOI:10.1111/j.1365-2249.1991.tb08160.x
PMID:1673877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535402/
Abstract

We have previously shown that CD4+ T lymphocytes accumulated at the site of allergen induced late-phase reactions (LPR) in the skin of atopic subjects. In order to determine whether these were predominantly 'memory' or 'naive' cells, monoclonal antibodies recognizing isoforms of the CD45 common leucocyte antigen and immunocytochemical methods were used to study the composition of the T cell infiltrate. Allergen-induced late-phase skin reactions were biopsied 6, 24 or 48 h after allergen challenge. Memory (CD45RO+/UCHL1+) T cells predominated and few naive (CD45RA+/Leu18+) cells were identified. Double immunofluorescence was used to confirm that the UCHL1+ and Leu 18+ cells were CD4+ T lymphocytes. The selective recruitment of memory T cells to LPR sites is consistent with the active involvement of T lymphocytes in atopic allergic inflammation. A possible alternative explanation for apparently selective recruitment is the differential expression of endothelial adhesion molecules on memory and naive T lymphocytes.

摘要

我们先前已表明，在特应性个体的皮肤中，变应原诱导的迟发相反应（LPR）部位会积聚CD4+ T淋巴细胞。为了确定这些细胞主要是“记忆”细胞还是“初始”细胞，我们使用识别CD45共同白细胞抗原异构体的单克隆抗体和免疫细胞化学方法来研究T细胞浸润的组成。在变应原激发后6、24或48小时对变应原诱导的迟发性皮肤反应进行活检。记忆性（CD45RO+/UCHL1+）T细胞占主导，而几乎未识别出初始（CD45RA+/Leu18+）细胞。采用双重免疫荧光法来确认UCHL1+和Leu 18+细胞为CD4+ T淋巴细胞。记忆性T细胞向LPR部位的选择性募集与T淋巴细胞积极参与特应性过敏性炎症是一致的。对于明显的选择性募集，一个可能的替代解释是记忆性和初始T淋巴细胞上内皮黏附分子的差异表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21e5/1535402/0bbaac76c35f/clinexpimmunol00062-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21e5/1535402/0bbaac76c35f/clinexpimmunol00062-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21e5/1535402/0bbaac76c35f/clinexpimmunol00062-0094-a.jpg

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