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肉碱:儿童银屑病甲肥厚性皮骨膜炎(POPP)的治疗选择。

Carnitine: a therapeutic option for childhood psoriatic onycho-pachydermo-periostitis (POPP).

机构信息

Osteo-Articular Department, Rheumatic Disease and Internal Medicine Unit, Hospital and University of Parma,Via Gramsci, 14,43100 Parma, Italy.

出版信息

Clin Rheumatol. 2007 Jan;26(1):93-4. doi: 10.1007/s10067-006-0322-2.

DOI:10.1007/s10067-006-0322-2
PMID:16738841
Abstract

Psoriatic onycho-pachydermo-periostitis (POPP)is a rare subset of psoriatic arthritis, characterized by onychopathy, painful thickening of the periungual soft tissues, and radiological features consisting of an exuberant periosteal reaction of the terminal phalanx. The POPP treatment is debated, and side effect risk of therapies may not be offset by their benefits. We report on a successful treatment with carnitine in a 15-year old boy suffering from POPP.

摘要

银屑病甲-厚皮-骨膜炎(POPP)是一种罕见的银屑病关节炎亚型,其特征为甲病、甲周软组织疼痛性增厚和影像学特征,包括末端指骨的骨膜反应过度。POPP 的治疗存在争议,且治疗的副作用风险可能不会超过其益处。我们报告了一例 15 岁男孩成功使用肉毒碱治疗 POPP 的案例。

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1
Carnitine: a therapeutic option for childhood psoriatic onycho-pachydermo-periostitis (POPP).肉碱:儿童银屑病甲肥厚性皮骨膜炎(POPP)的治疗选择。
Clin Rheumatol. 2007 Jan;26(1):93-4. doi: 10.1007/s10067-006-0322-2.
2
Psoriatic onycho-pachydermo periostitis.银屑病性甲厚皮骨膜炎
Dermatol Online J. 2007 Jan 27;13(1):20.
3
Successful treatment of psoriatic onycho-pachydermo periostitis (POPP) with adalimumab.阿达木单抗成功治疗银屑病性甲厚皮性骨膜病(POPP)。
Arthritis Rheum. 2005 Jan;52(1):280-2. doi: 10.1002/art.20763.
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Psoriatic onycho-pachydermo-periostitis successfully treated with low-dose methotrexate.低剂量甲氨蝶呤成功治疗银屑病性甲厚皮性骨膜炎
Med Sci Monit. 2006 Apr;12(4):CS27-30. Epub 2006 Mar 28.
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Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment.银屑病甲-厚皮骨膜病(POPP):一例成功接受 IL-17 阻断治疗的病例报告,并对其特征、发病机制和治疗进行文献复习。
Clin Rheumatol. 2021 Nov;40(11):4749-4757. doi: 10.1007/s10067-021-05729-0. Epub 2021 Apr 8.
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Psoriatic onycho-pachydermo-periostitis. A variant of psoriatic distal interphalangeal arthritis?银屑病性甲厚皮骨膜炎。银屑病性远端指间关节炎的一种变异型?
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[Psoriatic onycho-pachydermo- periostitis].[银屑病性甲厚皮性骨膜炎]
Z Rheumatol. 2002 Oct;61(5):601-4. doi: 10.1007/s00393-002-0352-3.
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[Psoriatic onycho-pachydermo-periostitis].[银屑病性甲厚皮性骨膜炎]
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[Psoriatic onycho-pachydermo-periostitis (POPP)].[银屑病性甲厚皮骨膜病(POPP)]
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引用本文的文献

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Psoriatic onycho-pachydermo periostitis (POPP): a case report treated successfully with IL-17 blockade and a literature review on characteristics, pathogenesis, and treatment.银屑病甲-厚皮骨膜病(POPP):一例成功接受 IL-17 阻断治疗的病例报告,并对其特征、发病机制和治疗进行文献复习。
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Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis.代谢组学分析揭示了氨基酸和肉碱的改变是银屑病的代谢特征。
Theranostics. 2021 Jan 1;11(2):754-767. doi: 10.7150/thno.51154. eCollection 2021.

本文引用的文献

1
Childhood onset of psoriatic onycho-pachydermo-periostitis (POPP).儿童期起病的银屑病性甲厚皮性骨膜病(POPP)。
J Eur Acad Dermatol Venereol. 2005 Nov;19(6):780-2. doi: 10.1111/j.1468-3083.2005.01276.x.
2
Successful treatment of psoriatic onycho-pachydermo periostitis (POPP) with adalimumab.阿达木单抗成功治疗银屑病性甲厚皮性骨膜病(POPP)。
Arthritis Rheum. 2005 Jan;52(1):280-2. doi: 10.1002/art.20763.
3
Clinical improvement in psoriatic arthritis symptoms during treatment for infertility with carnitine.在使用肉碱治疗不孕症期间,银屑病关节炎症状出现临床改善。
Clin Exp Rheumatol. 2004 Jan-Feb;22(1):138.
4
[Psoriatic onycho-pachydermo- periostitis].[银屑病性甲厚皮性骨膜炎]
Z Rheumatol. 2002 Oct;61(5):601-4. doi: 10.1007/s00393-002-0352-3.
5
[Psoriatic onycho-pachydermo- periostitis].[银屑病性甲厚皮性骨膜炎]
Z Rheumatol. 2002 Oct;61(5):598-600. doi: 10.1007/s00393-002-0314-9.
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Psoriatic onycho-pachydermo-periostitis.银屑病性甲厚皮性骨膜炎
Dermatol Online J. 2001 Feb;7(1):11.
7
Psoriatic onycho-pachydermo periostitis: treatment with methotrexate.银屑病性甲厚皮骨膜炎:甲氨蝶呤治疗
Br J Dermatol. 2000 Oct;143(4):901-2. doi: 10.1046/j.1365-2133.2000.03802.x.
8
Severe nail dystrophy associated with painful fingertips. Diagnosis: psoriatic onychopachydermoperiostitis (POPP).严重甲营养不良伴指尖疼痛。诊断:银屑病性甲厚皮性骨膜病(POPP)。
Arch Dermatol. 2000 Jul;136(7):925-30. doi: 10.1001/archderm.136.7.925-b.
9
Carnitine and antioxidants levels in patients with rheumatoid arthritis.
Scand J Rheumatol. 1998;27(6):441-5. doi: 10.1080/030097498442271.
10
Psoriatic onycho-pachydermo-periostitis. A variant of psoriatic distal interphalangeal arthritis?银屑病性甲厚皮骨膜炎。银屑病性远端指间关节炎的一种变异型?
Arch Dermatol. 1996 Feb;132(2):176-80.